The effect of 17-alpha hydroxyprogesterone caproate on the risk of gestational diabetes in singleton or twin pregnancies

Cynthia Gyamfi, Amanda L. Horton, Valerija Momirova, Dwight J. Rouse, Steve N. Caritis, Alan M. Peaceman, Anthony Sciscione, Paul J. Meis, Catherine Y. Spong, Mitchell Dombrowski, Baha Sibai, Michael W. Varner, Jay D. Iams, Brian M. Mercer, Marshall W. Carpenter, Julie Lo, Susan M. Ramin, Mary Jo O'Sullivan, Menachem Miodovnik, Deborah Conway

Research output: Contribution to journalArticle

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Abstract

Objective: To compare the rates of gestational diabetes among women who received serial doses of 17-alpha hydroxyprogesterone caproate vs placebo. Study Design: Secondary analysis of 2 double-blind randomized placebo-controlled trials of 17-alpha hydroxyprogesterone caproate given to women at risk for preterm delivery. The incidence of gestational diabetes was compared between women who received 17-alpha hydroxyprogesterone caproate or placebo. Results: We included 1094 women; 441 had singleton and 653 had twin gestations. Combining the 2 studies, 616 received 17-alpha hydroxyprogesterone caproate and 478 received placebo. Among singleton and twin pregnancies, rates of gestational diabetes were similar in women receiving 17-alpha hydroxyprogesterone caproate vs placebo (5.8% vs 4.7%; P = .64 and 7.4% vs 7.6%; P = .94, respectively). In the multivariable model, progesterone was not associated with gestational diabetes (adjusted odds ratio, 1.04; 95% confidence interval, 0.62-1.73). Conclusion: Weekly administration of 17-alpha hydroxyprogesterone caproate is not associated with higher rates of gestational diabetes in either singleton or twin pregnancies.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume201
Issue number4
DOIs
StatePublished - Oct 2009

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Twin Pregnancy
Gestational Diabetes
Placebos
Pregnancy Rate
Progesterone
17-alpha-hydroxy-progesterone caproate
Randomized Controlled Trials
Odds Ratio
Confidence Intervals
Pregnancy
Incidence

Keywords

  • 17-α hydroxy progesterone caproate
  • gestational diabetes
  • singletons
  • twins

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

The effect of 17-alpha hydroxyprogesterone caproate on the risk of gestational diabetes in singleton or twin pregnancies. / Gyamfi, Cynthia; Horton, Amanda L.; Momirova, Valerija; Rouse, Dwight J.; Caritis, Steve N.; Peaceman, Alan M.; Sciscione, Anthony; Meis, Paul J.; Spong, Catherine Y.; Dombrowski, Mitchell; Sibai, Baha; Varner, Michael W.; Iams, Jay D.; Mercer, Brian M.; Carpenter, Marshall W.; Lo, Julie; Ramin, Susan M.; O'Sullivan, Mary Jo; Miodovnik, Menachem; Conway, Deborah.

In: American Journal of Obstetrics and Gynecology, Vol. 201, No. 4, 10.2009.

Research output: Contribution to journalArticle

Gyamfi, C, Horton, AL, Momirova, V, Rouse, DJ, Caritis, SN, Peaceman, AM, Sciscione, A, Meis, PJ, Spong, CY, Dombrowski, M, Sibai, B, Varner, MW, Iams, JD, Mercer, BM, Carpenter, MW, Lo, J, Ramin, SM, O'Sullivan, MJ, Miodovnik, M & Conway, D 2009, 'The effect of 17-alpha hydroxyprogesterone caproate on the risk of gestational diabetes in singleton or twin pregnancies', American Journal of Obstetrics and Gynecology, vol. 201, no. 4. https://doi.org/10.1016/j.ajog.2009.06.036
Gyamfi, Cynthia ; Horton, Amanda L. ; Momirova, Valerija ; Rouse, Dwight J. ; Caritis, Steve N. ; Peaceman, Alan M. ; Sciscione, Anthony ; Meis, Paul J. ; Spong, Catherine Y. ; Dombrowski, Mitchell ; Sibai, Baha ; Varner, Michael W. ; Iams, Jay D. ; Mercer, Brian M. ; Carpenter, Marshall W. ; Lo, Julie ; Ramin, Susan M. ; O'Sullivan, Mary Jo ; Miodovnik, Menachem ; Conway, Deborah. / The effect of 17-alpha hydroxyprogesterone caproate on the risk of gestational diabetes in singleton or twin pregnancies. In: American Journal of Obstetrics and Gynecology. 2009 ; Vol. 201, No. 4.
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