The effect of acetazolamide on regional cerebral blood flow in patients with alzheimer’s disease or stroke as measured by single-photon emission computed tomography

F. J. Bonte, M. D. Devous, J. S. Reisch, A. K. Ajmani, M. F. Weiner, J. Hom, R. Tintner

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Regional cerebral blood flow (rCBF) was assessed in 35 patients with possible or probable Alzheimer’s disease (AD) and in 16 patients known to have had at least one stroke. Patients were evaluated before and after the administration of 1 g acetazolamide (ACZ) by means of a rotating four-detector single-photon emission computed tomograph (SPECT) and inhaled Xe-133. RCBF values in mL/minute/100 g were derived from eight cortical regions of intrest (ROI), and from the whole transverse section as a measure of whole brain flow (WBF). ROI/WBF ratios were calculated for each ROI in paired determinations done before and 15 minutes after the administration of ACZ. Results were compared with those previously obtained in a study of 15 normal, healthy volunteer subjects. ROI/WBF ratios > 2 standard deviations (SD) below the mean for a given ROI in the normal group were regarded as probably abnormal, whereas ratios > 4 SD below the mean were considered definitely abnormal. After ACZ administration, the number of ROI > 2 SD below the normal mean decreased significantly in the AD group and was unchanged in the stroke patients. However, the number of ROI/WBF ratios significant. Thus, the response of low-flow areas to ACZ differs in AD and in stroke, which could be of ultimate diagnostic signifi-cance.

Original languageEnglish (US)
Pages (from-to)99-103
Number of pages5
JournalInvestigative Radiology
Volume24
Issue number2
DOIs
StatePublished - Feb 1989

Keywords

  • Acetazolamide (Diamox) test for vasoreactivity
  • Alzheimer’s disease
  • Brain blood flow
  • SPECT
  • Stroke
  • Xenon-133

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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