The effect of age on rate of functional recovery after intracarotid amobarbital injection

Jessica B. Segal, Lauren R. Moo, John Hart

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Purpose: The duration of the drug effect during the intracarotid amobarbital procedure (IAP) is an important factor when considering the prioritization of behavioral testing during the IAP. Previous studies of thiopental, a barbiturate similar to sodium amobarbital, found that age and gender significantly affect the dose required to induce anesthesia, such that younger patients require higher dosage. Methods: A total of 55 patients who underwent the IAP procedure at Johns Hopkins Hospital were included in the study (110 hemispheric injections). The patient group included 30 female and 25 male patients, ranging in age from 11 to 50 years. To determine if a higher dose of sodium amobarbital was needed for younger patients during the IAP, we analyzed the time to return to preinjection EEG baseline status and time to return to 5/5 strength as a function of patient age and gender. Results: We found that younger patients (11-20 years old) returned to preinjection baseline EEG status and full (5/5) strength faster than older patients. No gender difference was found. Conclusions: The sodium amobarbital effect during IAP dissipates faster in young patients. Consideration of this difference in rate of recovery in 11-to 20-year-old patients has important clinical implications in terms of prioritizing behavioral testing.

Original languageEnglish (US)
Pages (from-to)659-661
Number of pages3
JournalEpilepsia
Volume43
Issue number6
DOIs
StatePublished - 2002

Keywords

  • Age
  • Amobarbital
  • Electroencephalography
  • Epilepsy
  • Motor function

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'The effect of age on rate of functional recovery after intracarotid amobarbital injection'. Together they form a unique fingerprint.

Cite this