The effect of beta-amyloid on face processing in young and old adults: A multivariate analysis of the BOLD signal

Jenny R. Rieck, Karen M. Rodrigue, Kristen M. Kennedy, Michael D. Devous, Denise C. Park

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The recent ability to measure in vivo beta-amyloid (Aβ), a marker of Alzheimer's disease (AD), has led to an increased focus on the significance of Aβ deposition in clinically normal adults. Evidence suggests that healthy adults with elevated cortical Aβ show differences in neural activity associated with memory encoding-specifically encoding of face stimuli. Here, we examined if Aβ deposition in clinically normal adults was related to differences in neural activity in ventral visual cortex during face viewing. Our sample included 23 high-Aβ older adults, 23 demographically matched low-Aβ older adults, and 16 young adults. Participants underwent cognitive testing, Aβ positron emission tomography imaging with <sup>18</sup>F-Florbetapir, and functional magnetic resonance imaging to measure neural activity while participants passively viewed photographs of faces. Using barycentric discriminant analysis-a between-groups classification technique-we found that patterns of neural activity in the left fusiform gyrus, a region highly responsive to faces, distinguished Aβ status of participants. Older adults with elevated Aβ were characterized by decreased activity in left fusiform compared to Aβ-negative older adults. Further, we found that the degree to which older adults expressed decreased fusiform activity was related to worse performance on tasks of processing speed. Our results provide unique evidence that, in addition to previously studied memory and default regions, decreased neural activity in a region important for face perception was associated with elevated Aβ and may be an early manifestation of AD.

Original languageEnglish (US)
Pages (from-to)2514-2526
Number of pages13
JournalHuman Brain Mapping
Volume36
Issue number7
DOIs
StatePublished - Jul 1 2015

Fingerprint

Amyloid
Young Adult
Multivariate Analysis
Alzheimer Disease
Aptitude
Task Performance and Analysis
Discriminant Analysis
Visual Cortex
Temporal Lobe
Positron-Emission Tomography
Magnetic Resonance Imaging

Keywords

  • Beta-amyloid
  • Cognitive aging
  • Face perception
  • Functional magnetic resonance imaging
  • Multivariate analysis
  • Preclinical Alzheimer's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

The effect of beta-amyloid on face processing in young and old adults : A multivariate analysis of the BOLD signal. / Rieck, Jenny R.; Rodrigue, Karen M.; Kennedy, Kristen M.; Devous, Michael D.; Park, Denise C.

In: Human Brain Mapping, Vol. 36, No. 7, 01.07.2015, p. 2514-2526.

Research output: Contribution to journalArticle

Rieck, Jenny R. ; Rodrigue, Karen M. ; Kennedy, Kristen M. ; Devous, Michael D. ; Park, Denise C. / The effect of beta-amyloid on face processing in young and old adults : A multivariate analysis of the BOLD signal. In: Human Brain Mapping. 2015 ; Vol. 36, No. 7. pp. 2514-2526.
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