The effect of body mass index on therapeutic response to bacterial vaginosis in pregnancy

Joan M. Mastrobattista, Mark A. Klebanoff, J. Christopher Carey, John C. Hauth, Cora A. MacPherson, J. Ernest, Margaret Cotroneo, Kenneth J. Leveno, Ronald Wapner, Michael Varner, Jay D. Iams, Atef Moawad, Baha M. Sibai, Menachem Miodovnik, Mitchell Dombrowski, Mary J. O'Sullivan, J. Peter VanDorsten, Oded Langer

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Our objective was to determine the effect of body mass index (BMI) on response to bacterial vaginosis (BV) treatment. A secondary analysis was conducted of two multicenter trials of therapy for BV and Trichomonas vaginalis. Gravida were screened for BV between 8 and 22 weeks and randomized between 16 and 23 weeks to metronidazole or placebo. Of 1497 gravida with asymptomatic BV and preconceptional BMI, 738 were randomized to metronidazole; BMI was divided into categories: <25, 25 to 29.9, and ≥30. Rates of BV persistence at follow-up were compared using the Mantel-Haenszel chi square. Multiple logistic regression was used to evaluate the effect of BMI on BV persistence at follow-up, adjusting for potential confounders. No association was identified between BMI and BV rate at follow-up (p = 0.21). BMI was associated with maternal age, smoking, marital status, and black race. Compared with women with BMI of <25, adjusted odds ratio (OR) of BV at follow-up were BMI 25 to 29.9: OR, 0.66, 95% CI 0.43 to 1.02; BMI ≥30: OR, 0.83, 95% CI 0.54 to 1.26. We concluded that the persistence of BV after treatment was not related to BMI.

Original languageEnglish (US)
Pages (from-to)233-237
Number of pages5
JournalAmerican Journal of Perinatology
Volume25
Issue number4
DOIs
StatePublished - 2008

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Keywords

  • Bacterial vaginosis
  • Body mass index
  • Pregnancy
  • Treatment

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Mastrobattista, J. M., Klebanoff, M. A., Carey, J. C., Hauth, J. C., MacPherson, C. A., Ernest, J., Cotroneo, M., Leveno, K. J., Wapner, R., Varner, M., Iams, J. D., Moawad, A., Sibai, B. M., Miodovnik, M., Dombrowski, M., O'Sullivan, M. J., VanDorsten, J. P., & Langer, O. (2008). The effect of body mass index on therapeutic response to bacterial vaginosis in pregnancy. American Journal of Perinatology, 25(4), 233-237. https://doi.org/10.1055/s-2008-1066875