The effect of diphenylhydantoin (Dilantin) and quinidine on left ventricular function in dogs

Donald S. Mierzwiak, Jere H. Mitchell, William Shapiro

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The effect of Dilantin upon left ventricular performance was investigated in an open-chest dog preparation and compared to that of quinidine under identical conditions. An initial intravenous injection of Dilantin produced a transient negative inotropic effect upon the left ventricle. The magnitude of the negative inotropic effect was similar following comparable dose levels of quinidine base, but the duration of the effect was more transient after Dilantin. The maximal negative inotropic effect following a second Dilantin injection was greater than that following an initial injection. After the second injection of quinidine, however, the degree of myocardial depression was similar to that following the initial injection. Again, the duration of the effect after Dilantin was more transient than after quinidine. The results with Dilantin are in keeping with the fact that most potent antiarrhythmic agents depress ventricular function. Insofar as such data may be applied to clinical situations, one must weigh the harmful transient negative inotropic effect of Dilantin against its beneficial antiarrhythmic property.

Original languageEnglish (US)
Pages (from-to)780-791
Number of pages12
JournalAmerican Heart Journal
Volume74
Issue number6
StatePublished - Dec 1967

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Quinidine
Phenytoin
Left Ventricular Function
Dogs
Injections
Ventricular Function
Intravenous Injections
Heart Ventricles
Thorax

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The effect of diphenylhydantoin (Dilantin) and quinidine on left ventricular function in dogs. / Mierzwiak, Donald S.; Mitchell, Jere H.; Shapiro, William.

In: American Heart Journal, Vol. 74, No. 6, 12.1967, p. 780-791.

Research output: Contribution to journalArticle

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