The effect of epinephrine in local anesthesia on the survival of full- and split-thickness skin grafts: An experimental study

S. Wolfort, R. J. Rohrich, J. Handren, J. W. May

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11 Scopus citations


The effect of local anesthesia containing epinephrine on the survival of split- and full-thickness skin grafts remains unclear. In this blinded study, Xylocaine with or without epinephrine was injected subdermally prior to harvesting of split-thickness and full-thickness skin grafts on the dorsum of rabbits. After procurement, the grafts were placed back into their original donor sites. Statistical analysis of graft survival 7 days postoperatively revealed a significant decrease in survival for the full-thickness skin grafts treated with Xylocaine with epinephrine as compared with similar grafts without epinephrine (p < 0.0005). No significant difference was noted for split- thickness skin-graft survival in grafts treated with Xylocaine with and without epinephrine (p > 0.1).

Original languageEnglish (US)
Pages (from-to)535-540
Number of pages6
JournalPlastic and reconstructive surgery
Issue number3
StatePublished - Sep 1990


ASJC Scopus subject areas

  • Surgery

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