Abstract
The effect of local anesthesia containing epinephrine on the survival of split- and full-thickness skin grafts remains unclear. In this blinded study, Xylocaine with or without epinephrine was injected subdermally prior to harvesting of split-thickness and full-thickness skin grafts on the dorsum of rabbits. After procurement, the grafts were placed back into their original donor sites. Statistical analysis of graft survival 7 days postoperatively revealed a significant decrease in survival for the full-thickness skin grafts treated with Xylocaine with epinephrine as compared with similar grafts without epinephrine (p < 0.0005). No significant difference was noted for split- thickness skin-graft survival in grafts treated with Xylocaine with and without epinephrine (p > 0.1).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 535-540 |
| Number of pages | 6 |
| Journal | Plastic and reconstructive surgery |
| Volume | 86 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1990 |
ASJC Scopus subject areas
- Surgery