TY - JOUR
T1 - The effect of gonadotropin-releasing hormone agonists on growth hormone secretion in adult premenopausal women
AU - Word, R. A.
AU - Odom, M. J.
AU - Byrd, W.
AU - Carr, B. R.
N1 - Funding Information:
Received January 9, 1990; revised and accepted March 29, 1990. * Supported in part by grants' 5-T32-HD07190 and HD-17814 from the National Institutes of Health, Bethesda, Maryland. t Reprint requests: R. Ann Word, M.D., Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75235.
PY - 1990
Y1 - 1990
N2 - Suppression of the putuitary-gonadal axis by the administration of gonadotropin-releasing hormone agonists (GnRH-a) has been used for a variety of endocrinological and gynecological disorders. The suppressive effect of GnRH-a on luteinizing hormone, follicle-stimulating hormone, and sex steroid production is well documented. However, little is known regarding the effect of GnRH-a on other aspects of pituitary function. The purpose of the present study was to determine the effect of GnRH-a treatment on growth hormone-releasing hormone (GH-RH)-stimulated GH release in premenopausal women. Eight control women and seven women, who were receiving a GnRH-a, were recruited. Before and after a bolus infusion of human GH-RH, blood samples were obtained over 3 hours and analyzed for GH by immunoassay. Basal GH and insulin-like growth factor levels were not statistically different between the two groups. However, basal levels of estradiol and the integrated GH response after GH-RH were significantly lower in the GnRH-a treated women. The reduction in GH-RH stimulated GH release in GnRH-a treated women may be attributed to diminished endogenous estrogen secretion, or to direct pituitary suppression by GnRH-a, or both.
AB - Suppression of the putuitary-gonadal axis by the administration of gonadotropin-releasing hormone agonists (GnRH-a) has been used for a variety of endocrinological and gynecological disorders. The suppressive effect of GnRH-a on luteinizing hormone, follicle-stimulating hormone, and sex steroid production is well documented. However, little is known regarding the effect of GnRH-a on other aspects of pituitary function. The purpose of the present study was to determine the effect of GnRH-a treatment on growth hormone-releasing hormone (GH-RH)-stimulated GH release in premenopausal women. Eight control women and seven women, who were receiving a GnRH-a, were recruited. Before and after a bolus infusion of human GH-RH, blood samples were obtained over 3 hours and analyzed for GH by immunoassay. Basal GH and insulin-like growth factor levels were not statistically different between the two groups. However, basal levels of estradiol and the integrated GH response after GH-RH were significantly lower in the GnRH-a treated women. The reduction in GH-RH stimulated GH release in GnRH-a treated women may be attributed to diminished endogenous estrogen secretion, or to direct pituitary suppression by GnRH-a, or both.
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U2 - 10.1016/s0015-0282(16)53639-5
DO - 10.1016/s0015-0282(16)53639-5
M3 - Article
C2 - 2113490
AN - SCOPUS:0025368657
SN - 0015-0282
VL - 54
SP - 73
EP - 78
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 1
ER -