The effect of hepatic inflow occlusion on laparoscopic radiofrequency ablation using simulated tumors

D. J. Scott, J. B. Fleming, L. M. Watumull, G. Lindberg, S. T. Tesfay, D. B. Jones

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: The purpose of this study was to determine the effect of hepatic inflow occlusion (the Pringle maneuver) on laparoscopic radiofrequency (RF) ablation. Methods: Using a previously validated agarose tissue-mimic model, 1-cm simulated hepatic tumors (three per animal) were laparoscopically ablated in five pigs with normal perfusion and then in five pigs with hepatic artery and portal vein occlusion. Energy was applied until tissue temperature reached 100°C (warm-up) and there-after for eight min. Specimens were examined immediately after treatment. Results: Vascular occlusion was successful in all cases per color-flow Doppler ultrasound. Pringle time was 11.4 ± 1.6 min. Warm-up time (2.7 ± 1.4 vs 20.2 ± 14.0 min) was significantly faster in the Pringle group. Ablation diameter (34.8 ± 2.9 vs 24.7 ± 3.1 mm), proportion of round/ovoid lesions (93% vs 20%), ablation symmetry (100% vs 40%), and margin distance (5.1 ± 3.0 vs 1.1 ± 1.2 mm) were significantly better for the Pringle group than the No Pringle group, respectively. Conclusion: Using a Pringle maneuver during laparoscopic RF ablation significantly enhances ablation geometry and results in larger margins.

Original languageEnglish (US)
Pages (from-to)1286-1291
Number of pages6
JournalSurgical Endoscopy and Other Interventional Techniques
Volume16
Issue number9
DOIs
StatePublished - Sep 2002

Fingerprint

Swine
Doppler Ultrasonography
Hepatic Veins
Liver
Hepatic Artery
Portal Vein
Sepharose
Blood Vessels
Neoplasms
Color
Perfusion
Temperature
neurotensin mimic 1

Keywords

  • Laparoscopy
  • Liver surgery
  • Porcine model
  • Pringle maneuver
  • Radiofrequency ablation
  • Tumor-mimic
  • Ultrasound
  • Vascular occlusion

ASJC Scopus subject areas

  • Surgery

Cite this

The effect of hepatic inflow occlusion on laparoscopic radiofrequency ablation using simulated tumors. / Scott, D. J.; Fleming, J. B.; Watumull, L. M.; Lindberg, G.; Tesfay, S. T.; Jones, D. B.

In: Surgical Endoscopy and Other Interventional Techniques, Vol. 16, No. 9, 09.2002, p. 1286-1291.

Research output: Contribution to journalArticle

@article{198e4d8737fc475eafc8c0211efaa3a2,
title = "The effect of hepatic inflow occlusion on laparoscopic radiofrequency ablation using simulated tumors",
abstract = "Background: The purpose of this study was to determine the effect of hepatic inflow occlusion (the Pringle maneuver) on laparoscopic radiofrequency (RF) ablation. Methods: Using a previously validated agarose tissue-mimic model, 1-cm simulated hepatic tumors (three per animal) were laparoscopically ablated in five pigs with normal perfusion and then in five pigs with hepatic artery and portal vein occlusion. Energy was applied until tissue temperature reached 100°C (warm-up) and there-after for eight min. Specimens were examined immediately after treatment. Results: Vascular occlusion was successful in all cases per color-flow Doppler ultrasound. Pringle time was 11.4 ± 1.6 min. Warm-up time (2.7 ± 1.4 vs 20.2 ± 14.0 min) was significantly faster in the Pringle group. Ablation diameter (34.8 ± 2.9 vs 24.7 ± 3.1 mm), proportion of round/ovoid lesions (93{\%} vs 20{\%}), ablation symmetry (100{\%} vs 40{\%}), and margin distance (5.1 ± 3.0 vs 1.1 ± 1.2 mm) were significantly better for the Pringle group than the No Pringle group, respectively. Conclusion: Using a Pringle maneuver during laparoscopic RF ablation significantly enhances ablation geometry and results in larger margins.",
keywords = "Laparoscopy, Liver surgery, Porcine model, Pringle maneuver, Radiofrequency ablation, Tumor-mimic, Ultrasound, Vascular occlusion",
author = "Scott, {D. J.} and Fleming, {J. B.} and Watumull, {L. M.} and G. Lindberg and Tesfay, {S. T.} and Jones, {D. B.}",
year = "2002",
month = "9",
doi = "10.1007/s004640080167",
language = "English (US)",
volume = "16",
pages = "1286--1291",
journal = "Surgical Endoscopy and Other Interventional Techniques",
issn = "0930-2794",
publisher = "Springer New York",
number = "9",

}

TY - JOUR

T1 - The effect of hepatic inflow occlusion on laparoscopic radiofrequency ablation using simulated tumors

AU - Scott, D. J.

AU - Fleming, J. B.

AU - Watumull, L. M.

AU - Lindberg, G.

AU - Tesfay, S. T.

AU - Jones, D. B.

PY - 2002/9

Y1 - 2002/9

N2 - Background: The purpose of this study was to determine the effect of hepatic inflow occlusion (the Pringle maneuver) on laparoscopic radiofrequency (RF) ablation. Methods: Using a previously validated agarose tissue-mimic model, 1-cm simulated hepatic tumors (three per animal) were laparoscopically ablated in five pigs with normal perfusion and then in five pigs with hepatic artery and portal vein occlusion. Energy was applied until tissue temperature reached 100°C (warm-up) and there-after for eight min. Specimens were examined immediately after treatment. Results: Vascular occlusion was successful in all cases per color-flow Doppler ultrasound. Pringle time was 11.4 ± 1.6 min. Warm-up time (2.7 ± 1.4 vs 20.2 ± 14.0 min) was significantly faster in the Pringle group. Ablation diameter (34.8 ± 2.9 vs 24.7 ± 3.1 mm), proportion of round/ovoid lesions (93% vs 20%), ablation symmetry (100% vs 40%), and margin distance (5.1 ± 3.0 vs 1.1 ± 1.2 mm) were significantly better for the Pringle group than the No Pringle group, respectively. Conclusion: Using a Pringle maneuver during laparoscopic RF ablation significantly enhances ablation geometry and results in larger margins.

AB - Background: The purpose of this study was to determine the effect of hepatic inflow occlusion (the Pringle maneuver) on laparoscopic radiofrequency (RF) ablation. Methods: Using a previously validated agarose tissue-mimic model, 1-cm simulated hepatic tumors (three per animal) were laparoscopically ablated in five pigs with normal perfusion and then in five pigs with hepatic artery and portal vein occlusion. Energy was applied until tissue temperature reached 100°C (warm-up) and there-after for eight min. Specimens were examined immediately after treatment. Results: Vascular occlusion was successful in all cases per color-flow Doppler ultrasound. Pringle time was 11.4 ± 1.6 min. Warm-up time (2.7 ± 1.4 vs 20.2 ± 14.0 min) was significantly faster in the Pringle group. Ablation diameter (34.8 ± 2.9 vs 24.7 ± 3.1 mm), proportion of round/ovoid lesions (93% vs 20%), ablation symmetry (100% vs 40%), and margin distance (5.1 ± 3.0 vs 1.1 ± 1.2 mm) were significantly better for the Pringle group than the No Pringle group, respectively. Conclusion: Using a Pringle maneuver during laparoscopic RF ablation significantly enhances ablation geometry and results in larger margins.

KW - Laparoscopy

KW - Liver surgery

KW - Porcine model

KW - Pringle maneuver

KW - Radiofrequency ablation

KW - Tumor-mimic

KW - Ultrasound

KW - Vascular occlusion

UR - http://www.scopus.com/inward/record.url?scp=0036713623&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036713623&partnerID=8YFLogxK

U2 - 10.1007/s004640080167

DO - 10.1007/s004640080167

M3 - Article

C2 - 11984682

AN - SCOPUS:0036713623

VL - 16

SP - 1286

EP - 1291

JO - Surgical Endoscopy and Other Interventional Techniques

JF - Surgical Endoscopy and Other Interventional Techniques

SN - 0930-2794

IS - 9

ER -