TY - JOUR
T1 - The effect of increasing tertiles of waist circumference on cardio-metabolic risk, adipokines and biomarkers of inflammation and oxidative stress in nascent metabolic syndrome
AU - Jialal, Ishwarlal
AU - Jialal, Ganesh
AU - Devaraj, Sridevi
AU - Adams-Huet, Beverley
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/4
Y1 - 2018/4
N2 - Aims: The effect of waist circumference (WC) on cardio-metabolic features and biomarkers of oxidative stress and inflammation and adipose tissue dysregulation is poorly defined in Metabolic Syndrome (MetS). Hence the aim of this study was to examine the effect of increasing tertiles of WC on the cardio metabolic risk profile, pro-oxidant state, pro-inflammatory state and adipose tissue dysregulation in nascent MetS patients (n = 59) without diabetes or CVD. Methods and results: None of the main cardio-metabolic features including blood pressure, blood glucose, HDL-cholesterol, triglycerides, HOMA-IR, and free fatty acids increased with increasing WC tertiles except for hsCRP. In addition, none of the biomarkers of oxidative stress increased with increasing WC. Other circulating and cellular bio-mediators of inflammation and adipokines did not show significant increase with increasing WC. Using the waist to height ratio (WHtR) also did not reveal any major findings with increasing tertiles. Conclusion: In conclusion, in a well-defined cohort of MetS we failed to show any superiority of either WC or WHtR compared to BMI in capturing the cardio-metabolic cluster, adipose tissue dysregulation and the increased burden of oxidative stress and inflammation in this pilot study. These observations need confirmation in larger studies.
AB - Aims: The effect of waist circumference (WC) on cardio-metabolic features and biomarkers of oxidative stress and inflammation and adipose tissue dysregulation is poorly defined in Metabolic Syndrome (MetS). Hence the aim of this study was to examine the effect of increasing tertiles of WC on the cardio metabolic risk profile, pro-oxidant state, pro-inflammatory state and adipose tissue dysregulation in nascent MetS patients (n = 59) without diabetes or CVD. Methods and results: None of the main cardio-metabolic features including blood pressure, blood glucose, HDL-cholesterol, triglycerides, HOMA-IR, and free fatty acids increased with increasing WC tertiles except for hsCRP. In addition, none of the biomarkers of oxidative stress increased with increasing WC. Other circulating and cellular bio-mediators of inflammation and adipokines did not show significant increase with increasing WC. Using the waist to height ratio (WHtR) also did not reveal any major findings with increasing tertiles. Conclusion: In conclusion, in a well-defined cohort of MetS we failed to show any superiority of either WC or WHtR compared to BMI in capturing the cardio-metabolic cluster, adipose tissue dysregulation and the increased burden of oxidative stress and inflammation in this pilot study. These observations need confirmation in larger studies.
KW - Adipokines
KW - Body mass index
KW - Inflammation
KW - Obesity
KW - Waist circumference
KW - Waist-height ratio
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U2 - 10.1016/j.jdiacomp.2018.01.008
DO - 10.1016/j.jdiacomp.2018.01.008
M3 - Article
C2 - 29478813
AN - SCOPUS:85042321477
SN - 1056-8727
VL - 32
SP - 379
EP - 383
JO - Journal of Diabetes and Its Complications
JF - Journal of Diabetes and Its Complications
IS - 4
ER -