The effect of interleukin-10 on meningeal inflammation in experimental bacterial meningitis

Maria M. París, Sheila M. Hickey, Mónica Trujillo, Amina Ahmed, Kurt Olsen, George H. McCracken

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Interleukin-10 (IL-10) is a cytokine with antiinflammatory effects. In a rabbit model of meningitis, IL-10 was given intracisternally or intravenously to evaluate the impact on inflammation induced by lipooligosaccharide (LOS), Haemophilus influenzae type b (Hib), or Listeria monocytogenes. Intracisternal IL-10 in concentrations >1 μg significantly reduced tumor necrosis factor-α (TNFα) and lactate values in cerebrospinal fluid (CSF). Intravenous IL-10 (1 mg/kg) in two doses after intracisternal LOS significantly reduced CSF TNF-α and lactate. When Hib was used, animals were treated with ceftriaxone and dexamethasone with or without IL-10 (1 mg/kg). TNF-α was significantly reduced in animals treated with IL-10, dexamethasone, or both compared with levels in rabbits receiving ceftriaxone alone. Comparable results were obtained when L. monocytogenes was inoculated and animals were treated with ampicillin with or without IL-10, dexamethasone, or nothing. In conclusion, IL-10 modulates CSF TNF-α concentrations in experimental LOS, Hib, or L. monocytogenes meningitis. The maximal inhibitory effect was seen when IL-10 and dexamethasone were combined.

Original languageEnglish (US)
Pages (from-to)1239-1246
Number of pages8
JournalJournal of Infectious Diseases
Volume176
Issue number5
StatePublished - 1997

Fingerprint

Bacterial Meningitides
Interleukin-10
Inflammation
Haemophilus influenzae type b
Dexamethasone
Tumor Necrosis Factor-alpha
Cerebrospinal Fluid
Ceftriaxone
Listeria monocytogenes
Interleukin-1
Lactic Acid
Listeria Meningitis
Rabbits
Ampicillin
Meningitis
Anti-Inflammatory Agents
Cytokines

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

París, M. M., Hickey, S. M., Trujillo, M., Ahmed, A., Olsen, K., & McCracken, G. H. (1997). The effect of interleukin-10 on meningeal inflammation in experimental bacterial meningitis. Journal of Infectious Diseases, 176(5), 1239-1246.

The effect of interleukin-10 on meningeal inflammation in experimental bacterial meningitis. / París, Maria M.; Hickey, Sheila M.; Trujillo, Mónica; Ahmed, Amina; Olsen, Kurt; McCracken, George H.

In: Journal of Infectious Diseases, Vol. 176, No. 5, 1997, p. 1239-1246.

Research output: Contribution to journalArticle

París, MM, Hickey, SM, Trujillo, M, Ahmed, A, Olsen, K & McCracken, GH 1997, 'The effect of interleukin-10 on meningeal inflammation in experimental bacterial meningitis', Journal of Infectious Diseases, vol. 176, no. 5, pp. 1239-1246.
París, Maria M. ; Hickey, Sheila M. ; Trujillo, Mónica ; Ahmed, Amina ; Olsen, Kurt ; McCracken, George H. / The effect of interleukin-10 on meningeal inflammation in experimental bacterial meningitis. In: Journal of Infectious Diseases. 1997 ; Vol. 176, No. 5. pp. 1239-1246.
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