The effect of ischemic time on survival after heart transplantation varies by donor age: An analysis of the United Network for Organ Sharing database

Mark J. Russo, Jonathan M. Chen, Robert A. Sorabella, Timothy P. Martens, Mauricio Garrido, Ryan R Davies, Isaac George, Faisal H. Cheema, Ralph S. Mosca, Seema Mital, Deborah D. Ascheim, Michael Argenziano, Allan S. Stewart, Mehmet C. Oz, Yoshifumi Naka

Research output: Contribution to journalArticle

120 Scopus citations

Abstract

Objectives: (1) To examine the interaction of donor age with ischemic time and their effect on survival and (2) to define ranges of ischemic time associated with differences in survival. Methods: The United Network for Organ Sharing provided de-identified patient-level data. The study population included 33,640 recipients undergoing heart transplantation between October 1, 1987, and December 31, 2004. Recipients were divided by donor age into terciles: 0 to 19 years (n = 10,814; 32.1%), 20 to 33 years (11,410, 33.9%), and 34 years or more (11,416, 33.9%). Kaplan-Meier survival functions and Cox regression were used for time-to-event analysis. Receiver operating characteristic curves and stratum-specific likelihood ratios were generated to compare 5-year survival at various thresholds for ischemic time. Results: In univariate Cox proportional hazards regression, the effect of ischemic time on survival varied by donor age tercile: 0 to 19 years (P = .141), 20 to 33 years (P < .001), and 34 years or more (P < .001). These relationships persisted in multivariable regression. Threshold analysis generated a single stratum (0.37-12.00 hours) in the 0- to 19-year-old group with a median survival of 11.4 years. However, in the 20- to 33-year-old-group, 3 strata were generated: 0.00 to 3.49 hours (limited), 3.50 to 6.24 hours (prolonged), and 6.25 hours or more (extended), with median survivals of 10.6, 9.9, and 7.3 years, respectively. Likewise, 3 strata were generated in the group aged 34 years or more: 0.00 to 3.49 (limited), 3.50 to 5.49 (prolonged), and 5.50 or more (extended), with median survivals of 9.1, 8.5, and 6.3 years, respectively. Conclusions: The effect of ischemic time on survival after heart transplantation is dependent on donor age, with greater tolerance for prolonged ischemic times among grafts from younger donors. Both donor age and anticipated ischemic time must be considered when assessing a potential donor.

Original languageEnglish (US)
Pages (from-to)554-559
Number of pages6
JournalJournal of Thoracic and Cardiovascular Surgery
Volume133
Issue number2
DOIs
StatePublished - Feb 1 2007

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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    Russo, M. J., Chen, J. M., Sorabella, R. A., Martens, T. P., Garrido, M., Davies, R. R., George, I., Cheema, F. H., Mosca, R. S., Mital, S., Ascheim, D. D., Argenziano, M., Stewart, A. S., Oz, M. C., & Naka, Y. (2007). The effect of ischemic time on survival after heart transplantation varies by donor age: An analysis of the United Network for Organ Sharing database. Journal of Thoracic and Cardiovascular Surgery, 133(2), 554-559. https://doi.org/10.1016/j.jtcvs.2006.09.019