The effect of lithium on the thrombin-induced 5-hydroxytryptamine release of human platelets in controls and subjects with affective disorders

A preliminary report

C. H. Tan, M. A. Javors, P. L. Lowrimore, C. L. Bowden

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to compare thrombin-induced [3H]-5-hydroxytryptamine (serotonin, 5HT) release from platelets in normal controls and subjects with diagnosed affective disorders who were treated with lithium carbonate. In vitro lithium (10 mM) did not affect the thrombin-induced [3H]-5HT release in either controls or patients. However, the EC50 of thrombin for activation of [3H]-5HT release from platelets was lower in two manic patients than in two depressed patients. This preliminary finding suggests that further comparative study of the coupling between membrane receptors involving phosphoinositide metabolism and second messenger systems and intracellular events from platelets of manic and depressive subjects may be useful for diagnostic or mechanistic purposes in the study of the affective disorders.

Original languageEnglish (US)
Pages (from-to)129-131
Number of pages3
JournalAsia Pacific Journal of Pharmacology
Volume4
Issue number2
StatePublished - 1989

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Mood Disorders
Lithium
Thrombin
Serotonin
Blood Platelets
Lithium Carbonate
Second Messenger Systems
Membranes

ASJC Scopus subject areas

  • Pharmacology

Cite this

The effect of lithium on the thrombin-induced 5-hydroxytryptamine release of human platelets in controls and subjects with affective disorders : A preliminary report. / Tan, C. H.; Javors, M. A.; Lowrimore, P. L.; Bowden, C. L.

In: Asia Pacific Journal of Pharmacology, Vol. 4, No. 2, 1989, p. 129-131.

Research output: Contribution to journalArticle

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