The effect of maternal body mass index on neonatal outcome in women receiving a single course of antenatal corticosteroids

Jason N. Hashima; Yinglei Lai; Ronald J. Wapner; Yoram Sorokin; Donald J. Dudley; Alan Peaceman; Catherine Y. Spong; Jay D. Iams; Kenneth J. Leveno; Margaret Harper; Steve N. Caritis; Michael Varner; Menachem Miodovnik; Brian M. Mercer; John M. Thorp; Mary J. O'Sullivan; Susan M. Ramin; Marshall Carpenter; Dwight J. Rouse; Baha Sibai

doi:10.1016/j.ajog.2009.10.859

The effect of maternal body mass index on neonatal outcome in women receiving a single course of antenatal corticosteroids

Jason N. Hashima, Yinglei Lai, Ronald J. Wapner, Yoram Sorokin, Donald J. Dudley, Alan Peaceman, Catherine Y. Spong, Jay D. Iams, Kenneth J. Leveno, Margaret Harper, Steve N. Caritis, Michael Varner, Menachem Miodovnik, Brian M. Mercer, John M. Thorp, Mary J. O'Sullivan, Susan M. Ramin, Marshall Carpenter, Dwight J. Rouse, Baha Sibai

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Objective: The aim of this study was to determine the effect of maternal body mass index on the incidence of neonatal prematurity morbidities in those who receive corticosteroids. Study Design: This was a secondary analysis of a trial of corticosteroids in women at risk for preterm birth. Women receiving a single course of corticosteroids were classified by their prepregnancy body mass index (<25 and ≥25) and compared on a composite outcome comprised of several neonatal morbidities and on each individual outcome. Results: Of 183 eligible women, 96 (52.5%) had a body mass index of <25 and 87 (47.5%) had a body mass index of ≥25. The composite outcome occurred more frequently in the body mass index of ≥25 group (28.7%), compared with those with a body mass index of <25 (18.8%), although this was not statistically significant (odds ratio, 1.75; 95% confidence interval, 0.83-3.72). Body mass index was not associated with outcomes after adjusting for confounding. Conclusion: Maternal body mass index did not affect neonatal prematurity morbidities in those receiving corticosteroids.

Original language	English (US)
Pages (from-to)	263.e1-263.e5
Journal	American journal of obstetrics and gynecology
Volume	202
Issue number	3
DOIs	https://doi.org/10.1016/j.ajog.2009.10.859
State	Published - Mar 2010

Keywords

BMI
antenatal corticosteroids
neonatal morbidity
obesity
prematurity

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1016/j.ajog.2009.10.859

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Hashima, J. N., Lai, Y., Wapner, R. J., Sorokin, Y., Dudley, D. J., Peaceman, A., Spong, C. Y., Iams, J. D., Leveno, K. J., Harper, M., Caritis, S. N., Varner, M., Miodovnik, M., Mercer, B. M., Thorp, J. M., O'Sullivan, M. J., Ramin, S. M., Carpenter, M., Rouse, D. J., & Sibai, B. (2010). The effect of maternal body mass index on neonatal outcome in women receiving a single course of antenatal corticosteroids. American journal of obstetrics and gynecology, 202(3), 263.e1-263.e5. https://doi.org/10.1016/j.ajog.2009.10.859

Hashima, JN, Lai, Y, Wapner, RJ, Sorokin, Y, Dudley, DJ, Peaceman, A, Spong, CY, Iams, JD, Leveno, KJ, Harper, M, Caritis, SN, Varner, M, Miodovnik, M, Mercer, BM, Thorp, JM, O'Sullivan, MJ, Ramin, SM, Carpenter, M, Rouse, DJ & Sibai, B 2010, 'The effect of maternal body mass index on neonatal outcome in women receiving a single course of antenatal corticosteroids', American journal of obstetrics and gynecology, vol. 202, no. 3, pp. 263.e1-263.e5. https://doi.org/10.1016/j.ajog.2009.10.859

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title = "The effect of maternal body mass index on neonatal outcome in women receiving a single course of antenatal corticosteroids",

abstract = "Objective: The aim of this study was to determine the effect of maternal body mass index on the incidence of neonatal prematurity morbidities in those who receive corticosteroids. Study Design: This was a secondary analysis of a trial of corticosteroids in women at risk for preterm birth. Women receiving a single course of corticosteroids were classified by their prepregnancy body mass index (<25 and ≥25) and compared on a composite outcome comprised of several neonatal morbidities and on each individual outcome. Results: Of 183 eligible women, 96 (52.5%) had a body mass index of <25 and 87 (47.5%) had a body mass index of ≥25. The composite outcome occurred more frequently in the body mass index of ≥25 group (28.7%), compared with those with a body mass index of <25 (18.8%), although this was not statistically significant (odds ratio, 1.75; 95% confidence interval, 0.83-3.72). Body mass index was not associated with outcomes after adjusting for confounding. Conclusion: Maternal body mass index did not affect neonatal prematurity morbidities in those receiving corticosteroids.",

keywords = "BMI, antenatal corticosteroids, neonatal morbidity, obesity, prematurity",

author = "Hashima, {Jason N.} and Yinglei Lai and Wapner, {Ronald J.} and Yoram Sorokin and Dudley, {Donald J.} and Alan Peaceman and Spong, {Catherine Y.} and Iams, {Jay D.} and Leveno, {Kenneth J.} and Margaret Harper and Caritis, {Steve N.} and Michael Varner and Menachem Miodovnik and Mercer, {Brian M.} and Thorp, {John M.} and O'Sullivan, {Mary J.} and Ramin, {Susan M.} and Marshall Carpenter and Rouse, {Dwight J.} and Baha Sibai",

note = "Funding Information: This study was supported by Grants ( HD21410 , HD21414 , HD27869 , HD27917 , HD27905 , HD27860 , HD27861 , HD27915 , HD34122 , HD34116 , HD34208 , HD34136 , HD40500 , HD40485 , HD40544 , HD40545 , HD40560 , HD40512 , HD40485 , HD36801 ) from the Eunice Kennedy Shriver National Institute of Child Health and Human Development and Grant M01-RR-000080 from the National Center for Research Resources . ",

year = "2010",

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doi = "10.1016/j.ajog.2009.10.859",

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T1 - The effect of maternal body mass index on neonatal outcome in women receiving a single course of antenatal corticosteroids

AU - Hashima, Jason N.

AU - Lai, Yinglei

AU - Wapner, Ronald J.

AU - Sorokin, Yoram

AU - Dudley, Donald J.

AU - Peaceman, Alan

AU - Spong, Catherine Y.

AU - Iams, Jay D.

AU - Leveno, Kenneth J.

AU - Harper, Margaret

AU - Caritis, Steve N.

AU - Varner, Michael

AU - Miodovnik, Menachem

AU - Mercer, Brian M.

AU - Thorp, John M.

AU - O'Sullivan, Mary J.

AU - Ramin, Susan M.

AU - Carpenter, Marshall

AU - Rouse, Dwight J.

AU - Sibai, Baha

N1 - Funding Information: This study was supported by Grants ( HD21410 , HD21414 , HD27869 , HD27917 , HD27905 , HD27860 , HD27861 , HD27915 , HD34122 , HD34116 , HD34208 , HD34136 , HD40500 , HD40485 , HD40544 , HD40545 , HD40560 , HD40512 , HD40485 , HD36801 ) from the Eunice Kennedy Shriver National Institute of Child Health and Human Development and Grant M01-RR-000080 from the National Center for Research Resources .

PY - 2010/3

Y1 - 2010/3

N2 - Objective: The aim of this study was to determine the effect of maternal body mass index on the incidence of neonatal prematurity morbidities in those who receive corticosteroids. Study Design: This was a secondary analysis of a trial of corticosteroids in women at risk for preterm birth. Women receiving a single course of corticosteroids were classified by their prepregnancy body mass index (<25 and ≥25) and compared on a composite outcome comprised of several neonatal morbidities and on each individual outcome. Results: Of 183 eligible women, 96 (52.5%) had a body mass index of <25 and 87 (47.5%) had a body mass index of ≥25. The composite outcome occurred more frequently in the body mass index of ≥25 group (28.7%), compared with those with a body mass index of <25 (18.8%), although this was not statistically significant (odds ratio, 1.75; 95% confidence interval, 0.83-3.72). Body mass index was not associated with outcomes after adjusting for confounding. Conclusion: Maternal body mass index did not affect neonatal prematurity morbidities in those receiving corticosteroids.

AB - Objective: The aim of this study was to determine the effect of maternal body mass index on the incidence of neonatal prematurity morbidities in those who receive corticosteroids. Study Design: This was a secondary analysis of a trial of corticosteroids in women at risk for preterm birth. Women receiving a single course of corticosteroids were classified by their prepregnancy body mass index (<25 and ≥25) and compared on a composite outcome comprised of several neonatal morbidities and on each individual outcome. Results: Of 183 eligible women, 96 (52.5%) had a body mass index of <25 and 87 (47.5%) had a body mass index of ≥25. The composite outcome occurred more frequently in the body mass index of ≥25 group (28.7%), compared with those with a body mass index of <25 (18.8%), although this was not statistically significant (odds ratio, 1.75; 95% confidence interval, 0.83-3.72). Body mass index was not associated with outcomes after adjusting for confounding. Conclusion: Maternal body mass index did not affect neonatal prematurity morbidities in those receiving corticosteroids.

KW - BMI

KW - antenatal corticosteroids

KW - neonatal morbidity

KW - obesity

KW - prematurity

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JF - American journal of obstetrics and gynecology

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ER -

The effect of maternal body mass index on neonatal outcome in women receiving a single course of antenatal corticosteroids

Abstract

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