The effect of N-acetylaspartate on the intracellular free calcium concentration in NTera2-neurons

Y. Rubin, M. C. LaPlaca, D. H. Smith, L. E. Thibault, R. E. Lenkinski

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Abstract

We have studied the effect of relatively high concentrations of extracellular N-acetylaspartate (NAA) on the intracellular free calcium concentration [Ca2+]i in NTera2-neurons. While low concentrations of extracellular NAA (0.1, 1 mM) had no effect on the [Ca2+]i, high concentrations of extracellular NAA (3, 10 mM) eliceted sharp and statistically significant elevations of [Ca2+]i. Different classes of antagonists of the N-methyl-d-aspartate (NMDA) receptor abolished the NAA induced elevations of the [Ca2+]i, indicating the involvement of the NMDA receptor in NAA-induced elevations of [Ca2+]i.

Original languageEnglish (US)
Pages (from-to)209-212
Number of pages4
JournalNeuroscience Letters
Volume198
Issue number3
DOIs
StatePublished - Oct 6 1995

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Keywords

  • Intracellular free calcium
  • N-acetylaspartate
  • N-methyl-d-aspartate receptor
  • NTera2-neurons

ASJC Scopus subject areas

  • Neuroscience(all)

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