The effect of optogenetic activation of astrocytes on the hippocampal neurons activity

E. I. Gerasimov, A. I. Erofeev, S. A. Pushkareva, A. V. Bol’shakova, A. A. Borodinova, P. M. Balaban, I. B. Bezprozvanny, O. L. Vlasova

Research output: Contribution to journalConference articlepeer-review

Abstract

The method of optogenetics has spread widely in neurobiology over the past 10 years and has found extensive application in various fields of this sciences. It allows to control and regulate cellular activity with high spatial and temporal resolution. In this study, optogenetic activation was applied to astrocytes expressing ChR2. Optogenetic stimulation parameters were determined, in which the frequency of spontaneous currents of hippocampal pyramidal neurons significantly changed. In the future, it is planned to use the obtained data on the modes of optogenetic stimulation of astrocytes to normalize the functions of the hippocampus in mice-models of Alzheimer's disease.

Original languageEnglish (US)
Article number012110
JournalJournal of Physics: Conference Series
Volume2086
Issue number1
DOIs
StatePublished - Dec 6 2021
Event8th International School and Conference "Saint Petersburg OPEN 2021" on Optoelectronics, Photonics, Engineering and Nanostructures, SPbOPEN 2021 - Saint Petersburg, Russian Federation
Duration: May 25 2021May 28 2021

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Fingerprint

Dive into the research topics of 'The effect of optogenetic activation of astrocytes on the hippocampal neurons activity'. Together they form a unique fingerprint.

Cite this