The effect of optogenetic activation of astrocytes on the hippocampal neurons activity

E. I. Gerasimov; A. I. Erofeev; S. A. Pushkareva; A. V. Bol’shakova; A. A. Borodinova; P. M. Balaban; I. B. Bezprozvanny; O. L. Vlasova

doi:10.1088/1742-6596/2086/1/012110

The effect of optogenetic activation of astrocytes on the hippocampal neurons activity

E. I. Gerasimov, A. I. Erofeev, S. A. Pushkareva, A. V. Bol’shakova, A. A. Borodinova, P. M. Balaban, I. B. Bezprozvanny, O. L. Vlasova

Research output: Contribution to journal › Conference article › peer-review

Abstract

The method of optogenetics has spread widely in neurobiology over the past 10 years and has found extensive application in various fields of this sciences. It allows to control and regulate cellular activity with high spatial and temporal resolution. In this study, optogenetic activation was applied to astrocytes expressing ChR2. Optogenetic stimulation parameters were determined, in which the frequency of spontaneous currents of hippocampal pyramidal neurons significantly changed. In the future, it is planned to use the obtained data on the modes of optogenetic stimulation of astrocytes to normalize the functions of the hippocampus in mice-models of Alzheimer's disease.

Original language	English (US)
Article number	012110
Journal	Journal of Physics: Conference Series
Volume	2086
Issue number	1
DOIs	https://doi.org/10.1088/1742-6596/2086/1/012110
State	Published - Dec 6 2021
Event	8th International School and Conference "Saint Petersburg OPEN 2021" on Optoelectronics, Photonics, Engineering and Nanostructures, SPbOPEN 2021 - Saint Petersburg, Russian Federation Duration: May 25 2021 → May 28 2021

ASJC Scopus subject areas

General Physics and Astronomy

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10.1088/1742-6596/2086/1/012110

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title = "The effect of optogenetic activation of astrocytes on the hippocampal neurons activity",

abstract = "The method of optogenetics has spread widely in neurobiology over the past 10 years and has found extensive application in various fields of this sciences. It allows to control and regulate cellular activity with high spatial and temporal resolution. In this study, optogenetic activation was applied to astrocytes expressing ChR2. Optogenetic stimulation parameters were determined, in which the frequency of spontaneous currents of hippocampal pyramidal neurons significantly changed. In the future, it is planned to use the obtained data on the modes of optogenetic stimulation of astrocytes to normalize the functions of the hippocampus in mice-models of Alzheimer's disease.",

author = "Gerasimov, {E. I.} and Erofeev, {A. I.} and Pushkareva, {S. A.} and Bol{\textquoteright}shakova, {A. V.} and Borodinova, {A. A.} and Balaban, {P. M.} and Bezprozvanny, {I. B.} and Vlasova, {O. L.}",

note = "Publisher Copyright: {\textcopyright} 2021 Institute of Physics Publishing. All rights reserved.; 8th International School and Conference {"}Saint Petersburg OPEN 2021{"} on Optoelectronics, Photonics, Engineering and Nanostructures, SPbOPEN 2021 ; Conference date: 25-05-2021 Through 28-05-2021",

year = "2021",

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doi = "10.1088/1742-6596/2086/1/012110",

language = "English (US)",

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T1 - The effect of optogenetic activation of astrocytes on the hippocampal neurons activity

AU - Gerasimov, E. I.

AU - Erofeev, A. I.

AU - Pushkareva, S. A.

AU - Bol’shakova, A. V.

AU - Borodinova, A. A.

AU - Balaban, P. M.

AU - Bezprozvanny, I. B.

AU - Vlasova, O. L.

PY - 2021/12/6

Y1 - 2021/12/6

N2 - The method of optogenetics has spread widely in neurobiology over the past 10 years and has found extensive application in various fields of this sciences. It allows to control and regulate cellular activity with high spatial and temporal resolution. In this study, optogenetic activation was applied to astrocytes expressing ChR2. Optogenetic stimulation parameters were determined, in which the frequency of spontaneous currents of hippocampal pyramidal neurons significantly changed. In the future, it is planned to use the obtained data on the modes of optogenetic stimulation of astrocytes to normalize the functions of the hippocampus in mice-models of Alzheimer's disease.

AB - The method of optogenetics has spread widely in neurobiology over the past 10 years and has found extensive application in various fields of this sciences. It allows to control and regulate cellular activity with high spatial and temporal resolution. In this study, optogenetic activation was applied to astrocytes expressing ChR2. Optogenetic stimulation parameters were determined, in which the frequency of spontaneous currents of hippocampal pyramidal neurons significantly changed. In the future, it is planned to use the obtained data on the modes of optogenetic stimulation of astrocytes to normalize the functions of the hippocampus in mice-models of Alzheimer's disease.

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DO - 10.1088/1742-6596/2086/1/012110

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JO - Journal of Physics: Conference Series

JF - Journal of Physics: Conference Series

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T2 - 8th International School and Conference "Saint Petersburg OPEN 2021" on Optoelectronics, Photonics, Engineering and Nanostructures, SPbOPEN 2021

Y2 - 25 May 2021 through 28 May 2021

ER -

The effect of optogenetic activation of astrocytes on the hippocampal neurons activity

Abstract

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