The effect of rimantadine on the structure of model and biological membranes.

V. V. Cherny, M. Paulitschke, M. V. Simonova, E. Hessel, YuA Ermakov YuA, V. S. Sokolov, D. Lerche, V. S. Markin

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The action of the antiviral drug rimantadine on the structure of bilayer lipid membranes (BLM) and RBC membranes was investigated. Structural changes in BLM were recorded by ionophore conductivity changes and by changes in the third harmonic of capacity current signal due to lateral compression of BLM in an electric field. It was shown that the adsorption of rimantadine on BLM results in an increase in ionophore mobility in bilayer membranes of dioleolyllecithin (DOL) and common lipids of bovine brain (CL) and in a decrease in those of azolectin (A). Relative changes in the third harmonic signal also depend on the membrane composition and have different signs. The results may be explained by the rimantadine action on the lipid bilayer structure: "rigidification" of A-membranes and "fluidization" of BLM from DOL and CL. Structural reorganization of RBC membranes as investigated by the ability of the cells to enter a micropipette (inner diameter greater than or equal to 3 microns) thereby undergoing deformation. It was shown that rimantadine influences RBC deformability due to drug induced inhomogenous mechanical membrane properties. Also, rimantadine accelerated the process of artificially induced aggregation of erythrocytes. The relation of the effects on artificial and biological membranes, and the structural changes in the lipid phase of membrane are discussed.

Original languageEnglish (US)
Pages (from-to)23-37
Number of pages15
JournalGeneral Physiology and Biophysics
Volume8
Issue number1
StatePublished - Feb 1989

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Rimantadine
Biological Models
Lipid Bilayers
Membrane Lipids
Membranes
Ionophores
Erythrocyte Aggregation
Artificial Membranes
Adsorption
Antiviral Agents
Lipids
Brain
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Biophysics
  • Physiology

Cite this

Cherny, V. V., Paulitschke, M., Simonova, M. V., Hessel, E., Ermakov YuA, Y., Sokolov, V. S., ... Markin, V. S. (1989). The effect of rimantadine on the structure of model and biological membranes. General Physiology and Biophysics, 8(1), 23-37.

The effect of rimantadine on the structure of model and biological membranes. / Cherny, V. V.; Paulitschke, M.; Simonova, M. V.; Hessel, E.; Ermakov YuA, YuA; Sokolov, V. S.; Lerche, D.; Markin, V. S.

In: General Physiology and Biophysics, Vol. 8, No. 1, 02.1989, p. 23-37.

Research output: Contribution to journalArticle

Cherny, VV, Paulitschke, M, Simonova, MV, Hessel, E, Ermakov YuA, Y, Sokolov, VS, Lerche, D & Markin, VS 1989, 'The effect of rimantadine on the structure of model and biological membranes.', General Physiology and Biophysics, vol. 8, no. 1, pp. 23-37.
Cherny VV, Paulitschke M, Simonova MV, Hessel E, Ermakov YuA Y, Sokolov VS et al. The effect of rimantadine on the structure of model and biological membranes. General Physiology and Biophysics. 1989 Feb;8(1):23-37.
Cherny, V. V. ; Paulitschke, M. ; Simonova, M. V. ; Hessel, E. ; Ermakov YuA, YuA ; Sokolov, V. S. ; Lerche, D. ; Markin, V. S. / The effect of rimantadine on the structure of model and biological membranes. In: General Physiology and Biophysics. 1989 ; Vol. 8, No. 1. pp. 23-37.
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