The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men

Jeffrey D. Browning, Jeannie Baxter, Santhosh Satapati, Shawn C. Burgess

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Fasting promotes triglyceride (TG) accumulation in lean tissues of some animals, but the effect in humans is unknown. Additionally, fasting lipolysis is sexually dimorphic in humans, suggesting that lean tissue TG accumulation and metabolism may differ between women and men. This study investigated lean tissue TG content and metabolism in women and men during extended fasting. Liver and muscle TG content were measured by magnetic resonance spectroscopy during a 48-h fast in healthy men and women. Whole-body and hepatic carbohydrate, lipid, and energy metabolism were also evaluated using biochemical, calorimetric, and stable isotope tracer techniques. As expected, postabsorptive plasma fatty acids (FAs) were higher in women than in men but increased more rapidly in men with the onset of early starvation. Concurrently, sexual dimorphism was apparent in lean tissue TG accumulation during the fast, occurring in livers of men but in muscles of women. Despite differences in lean tissue TG distribution, men and women had identical fasting responses in whole-body and hepatic glucose and oxidative metabolism. In conclusion, TG accumulated in livers of men but in muscles of women during extended fasting. This sexual dimorphism was related to differential fasting plasma FA concentrations but not to whole body or hepatic utilization of this substrate.

Original languageEnglish (US)
Pages (from-to)577-586
Number of pages10
JournalJournal of Lipid Research
Volume53
Issue number3
DOIs
StatePublished - Mar 2012

Fingerprint

Lipid Metabolism
Liver
Energy Metabolism
Muscle
Fasting
Skeletal Muscle
Triglycerides
Lipids
Glucose
Tissue
Metabolism
Sex Characteristics
Muscles
Fatty Acids
Magnetic resonance spectroscopy
Plasmas
Lipolysis
Isotopes
Carbohydrate Metabolism
Tissue Distribution

Keywords

  • Liver fat
  • Magnetic resonance spectroscopy
  • Muscle fat

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Endocrinology

Cite this

The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men. / Browning, Jeffrey D.; Baxter, Jeannie; Satapati, Santhosh; Burgess, Shawn C.

In: Journal of Lipid Research, Vol. 53, No. 3, 03.2012, p. 577-586.

Research output: Contribution to journalArticle

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