The effect of sildenafil on quality of life

Christina M. Dording, Rachel A. LaRocca, Katherine A. Hails, Ottavio V. Vitolo, Stephen R. Wisniewski, Goundappa K. Balasubramani, Madhukar Trivedi, Maurizio Fava, David Mischoulon

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Antidepressant-induced sexual dysfunction affects approximately 50% of patients taking antidepressants. Previous research has explored sildenafil's effectiveness in treating various forms of erectile dys-function, but there is no research supporting sildenafil's use for improving the quality of life for patients with sexual dysfunction linked to antidepressant use. The authors of this article aimed to assess the improvements in quality of life in patients taking sildenafil to treat antidepressant-induced sexual dysfunction. Methods: One hundred and two out of 2,239 male and female patients in the follow-up phase of the Sequenced Treatment Alternatives to Relieve Depression antidepressant trials who complained of sexual dysfunction were given sildenafil, 50 to 100 mg, as needed. After 12 months, we measured patients' change in libido, sexual drive, family relationships, overall well-being, satisfaction with treatment, and overall contentment with items on the 17-item Hamilton Depression Rating Scale, Quality of Life Enjoyment and Satisfaction Questionnaire, 30-item Inventory of Depressive Symptoms, and 12-item Short Form Health Survey. Results: There was a significant association between sildenafil use and improvement in libido and sexual drive by month 6. There was no significant improvement in the quality-of-life scores we examined, but treatment satisfaction and overall contentment increased over time. Conclusions: Despite no direct association with sildenafil use and quality-of-life scores, sildenafil may be a beneficial treatment for antidepressant-induced sexual dysfunction. A double-blind, placebo-controlled study of sildenafil in antidepressant-induced sexual dysfunction is needed to further explore its potential benefits.

Original languageEnglish (US)
Pages (from-to)3-10
Number of pages8
JournalAnnals of Clinical Psychiatry
Volume25
Issue number1
StatePublished - Feb 2013

Fingerprint

Antidepressive Agents
Quality of Life
Libido
Depression
Sildenafil Citrate
Family Relations
Therapeutics
Health Surveys
Research
Placebos
Equipment and Supplies

Keywords

  • Antidepressant
  • Libido
  • Major depressive disorder
  • Quality of life
  • Sexual dysfunction
  • Sildenafil

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Dording, C. M., LaRocca, R. A., Hails, K. A., Vitolo, O. V., Wisniewski, S. R., Balasubramani, G. K., ... Mischoulon, D. (2013). The effect of sildenafil on quality of life. Annals of Clinical Psychiatry, 25(1), 3-10.

The effect of sildenafil on quality of life. / Dording, Christina M.; LaRocca, Rachel A.; Hails, Katherine A.; Vitolo, Ottavio V.; Wisniewski, Stephen R.; Balasubramani, Goundappa K.; Trivedi, Madhukar; Fava, Maurizio; Mischoulon, David.

In: Annals of Clinical Psychiatry, Vol. 25, No. 1, 02.2013, p. 3-10.

Research output: Contribution to journalArticle

Dording, CM, LaRocca, RA, Hails, KA, Vitolo, OV, Wisniewski, SR, Balasubramani, GK, Trivedi, M, Fava, M & Mischoulon, D 2013, 'The effect of sildenafil on quality of life', Annals of Clinical Psychiatry, vol. 25, no. 1, pp. 3-10.
Dording CM, LaRocca RA, Hails KA, Vitolo OV, Wisniewski SR, Balasubramani GK et al. The effect of sildenafil on quality of life. Annals of Clinical Psychiatry. 2013 Feb;25(1):3-10.
Dording, Christina M. ; LaRocca, Rachel A. ; Hails, Katherine A. ; Vitolo, Ottavio V. ; Wisniewski, Stephen R. ; Balasubramani, Goundappa K. ; Trivedi, Madhukar ; Fava, Maurizio ; Mischoulon, David. / The effect of sildenafil on quality of life. In: Annals of Clinical Psychiatry. 2013 ; Vol. 25, No. 1. pp. 3-10.
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