The effect of 13C enrichment in the glassing matrix on dynamic nuclear polarization of [1-13C]pyruvate

Lloyd Lumata, Zoltan Kovacs, Craig Malloy, A. Dean Sherry, Matthew Merritt

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Dimethyl sulfoxide (DMSO) can effectively form a glassy matrix necessary for dynamic nuclear polarization (DNP) experiments. We tested the effects of 13C enrichment in DMSO on DNP of [1-13C]pyruvate doped with trityl radical OX063 Me. We found that the polarization build-up time τ of pyruvate in 13C-labeled DMSO glassing solution is twice as fast as the unenriched DMSO while the nuclear magnetic resonance enhancement was unchanged. This indicates that 13C-13C spin diffusion is a limiting factor in the kinetics of DNP in this system, but it has a minimal effect on the absolute value of polarization achievable for the target.

Original languageEnglish (US)
Pages (from-to)N85-N92
JournalPhysics in medicine and biology
Issue number5
StatePublished - Mar 7 2011


ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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