The Effect of Thiazide and Potassium Citrate Use on the Health Related Quality of Life of Patients with Urolithiasis

Eric P. Raffin, Kristina L. Penniston, Jodi Antonelli, Davis P. Viprakasit, Timothy D. Averch, Vincent G. Bird, Ben H. Chew, Sri Sivalingam, Roger L. Sur, Stephen Y. Nakada, Vernon M. Pais

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: To our knowledge it is unknown whether the benefits of medical management of urolithiasis outweigh the potential side effects of the medications used, including potassium citrate and thiazide diuretics. Therefore, we evaluated the relationship between potassium citrate or thiazides and overall stone related health related quality of life. Materials and Methods: Cross-sectional data were obtained on stone forming enrollees in the North American Stone Quality of Life Consortium. We used the WISQOL (Wisconsin Stone Quality of Life) questionnaire to compare health related quality of life between patients treated and not treated with potassium citrate or thiazide type diuretics. Additionally, the likelihood of gastrointestinal complaints was compared between those prescribed and not prescribed potassium citrate. The likelihood of fatigue and sexual complaints was also compared in those prescribed and not prescribed thiazides. Results: Of the 1,511 subjects, including 787 males and 724 females, 279 were on potassium citrate and 238 were on thiazides at study enrollment. Patients prescribed potassium citrate had higher health related quality of life in each domain vs those not prescribed potassium citrate (p <0.001). Patients prescribed thiazides had higher health related quality of life in each domain compared to those not prescribed thiazide (all p <0.01). Those prescribed potassium citrate were less likely than those not prescribed potassium citrate to report nausea, stomach upset or cramps (OR 0.57, p <0.001). Patients prescribed thiazides were less likely than those not prescribed thiazides to report fatigue (OR 0.63, p = 0.004) or reduced sexual interest and/or activity (OR 0.64, p = 0.005). Conclusions: Among stone formers the use of potassium citrate and thiazides was associated with better health related quality of life across all WISQOL domains without an increased likelihood of gastrointestinal complaints and fatigue or sexual complaints, respectively. These findings may be useful when counseling patients regarding the initiation of potassium citrate or thiazides for medical management of nephrolithiasis.

Original languageEnglish (US)
Pages (from-to)1290-1294
Number of pages5
JournalJournal of Urology
Volume200
Issue number6
DOIs
StatePublished - Dec 1 2018

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Potassium Citrate
Thiazides
Urolithiasis
Quality of Life
Fatigue
Sodium Chloride Symporter Inhibitors
Muscle Cramp
Nephrolithiasis
Nausea
Counseling

Keywords

  • kidney calculi
  • potassium citrate
  • quality of life
  • sodium chloride symporter inhibitors
  • surveys and questionnaires

ASJC Scopus subject areas

  • Urology

Cite this

The Effect of Thiazide and Potassium Citrate Use on the Health Related Quality of Life of Patients with Urolithiasis. / Raffin, Eric P.; Penniston, Kristina L.; Antonelli, Jodi; Viprakasit, Davis P.; Averch, Timothy D.; Bird, Vincent G.; Chew, Ben H.; Sivalingam, Sri; Sur, Roger L.; Nakada, Stephen Y.; Pais, Vernon M.

In: Journal of Urology, Vol. 200, No. 6, 01.12.2018, p. 1290-1294.

Research output: Contribution to journalArticle

Raffin, EP, Penniston, KL, Antonelli, J, Viprakasit, DP, Averch, TD, Bird, VG, Chew, BH, Sivalingam, S, Sur, RL, Nakada, SY & Pais, VM 2018, 'The Effect of Thiazide and Potassium Citrate Use on the Health Related Quality of Life of Patients with Urolithiasis', Journal of Urology, vol. 200, no. 6, pp. 1290-1294. https://doi.org/10.1016/j.juro.2018.06.023
Raffin, Eric P. ; Penniston, Kristina L. ; Antonelli, Jodi ; Viprakasit, Davis P. ; Averch, Timothy D. ; Bird, Vincent G. ; Chew, Ben H. ; Sivalingam, Sri ; Sur, Roger L. ; Nakada, Stephen Y. ; Pais, Vernon M. / The Effect of Thiazide and Potassium Citrate Use on the Health Related Quality of Life of Patients with Urolithiasis. In: Journal of Urology. 2018 ; Vol. 200, No. 6. pp. 1290-1294.
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AU - Penniston, Kristina L.

AU - Antonelli, Jodi

AU - Viprakasit, Davis P.

AU - Averch, Timothy D.

AU - Bird, Vincent G.

AU - Chew, Ben H.

AU - Sivalingam, Sri

AU - Sur, Roger L.

AU - Nakada, Stephen Y.

AU - Pais, Vernon M.

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N2 - Purpose: To our knowledge it is unknown whether the benefits of medical management of urolithiasis outweigh the potential side effects of the medications used, including potassium citrate and thiazide diuretics. Therefore, we evaluated the relationship between potassium citrate or thiazides and overall stone related health related quality of life. Materials and Methods: Cross-sectional data were obtained on stone forming enrollees in the North American Stone Quality of Life Consortium. We used the WISQOL (Wisconsin Stone Quality of Life) questionnaire to compare health related quality of life between patients treated and not treated with potassium citrate or thiazide type diuretics. Additionally, the likelihood of gastrointestinal complaints was compared between those prescribed and not prescribed potassium citrate. The likelihood of fatigue and sexual complaints was also compared in those prescribed and not prescribed thiazides. Results: Of the 1,511 subjects, including 787 males and 724 females, 279 were on potassium citrate and 238 were on thiazides at study enrollment. Patients prescribed potassium citrate had higher health related quality of life in each domain vs those not prescribed potassium citrate (p <0.001). Patients prescribed thiazides had higher health related quality of life in each domain compared to those not prescribed thiazide (all p <0.01). Those prescribed potassium citrate were less likely than those not prescribed potassium citrate to report nausea, stomach upset or cramps (OR 0.57, p <0.001). Patients prescribed thiazides were less likely than those not prescribed thiazides to report fatigue (OR 0.63, p = 0.004) or reduced sexual interest and/or activity (OR 0.64, p = 0.005). Conclusions: Among stone formers the use of potassium citrate and thiazides was associated with better health related quality of life across all WISQOL domains without an increased likelihood of gastrointestinal complaints and fatigue or sexual complaints, respectively. These findings may be useful when counseling patients regarding the initiation of potassium citrate or thiazides for medical management of nephrolithiasis.

AB - Purpose: To our knowledge it is unknown whether the benefits of medical management of urolithiasis outweigh the potential side effects of the medications used, including potassium citrate and thiazide diuretics. Therefore, we evaluated the relationship between potassium citrate or thiazides and overall stone related health related quality of life. Materials and Methods: Cross-sectional data were obtained on stone forming enrollees in the North American Stone Quality of Life Consortium. We used the WISQOL (Wisconsin Stone Quality of Life) questionnaire to compare health related quality of life between patients treated and not treated with potassium citrate or thiazide type diuretics. Additionally, the likelihood of gastrointestinal complaints was compared between those prescribed and not prescribed potassium citrate. The likelihood of fatigue and sexual complaints was also compared in those prescribed and not prescribed thiazides. Results: Of the 1,511 subjects, including 787 males and 724 females, 279 were on potassium citrate and 238 were on thiazides at study enrollment. Patients prescribed potassium citrate had higher health related quality of life in each domain vs those not prescribed potassium citrate (p <0.001). Patients prescribed thiazides had higher health related quality of life in each domain compared to those not prescribed thiazide (all p <0.01). Those prescribed potassium citrate were less likely than those not prescribed potassium citrate to report nausea, stomach upset or cramps (OR 0.57, p <0.001). Patients prescribed thiazides were less likely than those not prescribed thiazides to report fatigue (OR 0.63, p = 0.004) or reduced sexual interest and/or activity (OR 0.64, p = 0.005). Conclusions: Among stone formers the use of potassium citrate and thiazides was associated with better health related quality of life across all WISQOL domains without an increased likelihood of gastrointestinal complaints and fatigue or sexual complaints, respectively. These findings may be useful when counseling patients regarding the initiation of potassium citrate or thiazides for medical management of nephrolithiasis.

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KW - potassium citrate

KW - quality of life

KW - sodium chloride symporter inhibitors

KW - surveys and questionnaires

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