The effect of treatment on survival in congestive heart failure

B. Pitt, J. N. Cohn, G. S. Francis, J. B. Kostis, M. Packer, M. A. Pfeffer, K. Swedberg, S. Yusuf

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Congestive heart failure (CHF) is a disorder characterized by a variety of clinical, biochemical, electrophysiological, and hemodynamic abnormalities. During the past two decades, numerous drugs have been employed in the treatment of this complex syndrome, and many agents have been shown to improve symptoms and ventricular function in patients with CHF. Because CHF is associated with a high risk of death, treatment should be directed not only toward the relief of symptoms, but also toward a reduction in mortality. Many variables have been shown to be related to survival; taken individually, however, each is limited in its utility in predicting prognosis. In recent years, large-scale studies with large sample sizes have directly assessed the effects of treatment on mortality in CHF. Results from these trials indicate that vasodilators and angiotensin-converting enzyme (ACE) inhibitors may improve mortality in patients with symptoms of heart failure. Additional trials are now in progress to evaluate the effect of treatment on patients with asymptomatic left ventricular dysfunction.

Original languageEnglish (US)
Pages (from-to)323-329
Number of pages7
JournalClinical Cardiology
Volume15
Issue number5
StatePublished - 1992

Fingerprint

Heart Failure
Survival
Mortality
Therapeutics
Ventricular Function
Left Ventricular Dysfunction
Vasodilator Agents
Angiotensin-Converting Enzyme Inhibitors
Sample Size
Hemodynamics
Pharmaceutical Preparations

Keywords

  • congestive heart failure
  • drug treatment
  • mortality
  • prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Pitt, B., Cohn, J. N., Francis, G. S., Kostis, J. B., Packer, M., Pfeffer, M. A., ... Yusuf, S. (1992). The effect of treatment on survival in congestive heart failure. Clinical Cardiology, 15(5), 323-329.

The effect of treatment on survival in congestive heart failure. / Pitt, B.; Cohn, J. N.; Francis, G. S.; Kostis, J. B.; Packer, M.; Pfeffer, M. A.; Swedberg, K.; Yusuf, S.

In: Clinical Cardiology, Vol. 15, No. 5, 1992, p. 323-329.

Research output: Contribution to journalArticle

Pitt, B, Cohn, JN, Francis, GS, Kostis, JB, Packer, M, Pfeffer, MA, Swedberg, K & Yusuf, S 1992, 'The effect of treatment on survival in congestive heart failure', Clinical Cardiology, vol. 15, no. 5, pp. 323-329.
Pitt B, Cohn JN, Francis GS, Kostis JB, Packer M, Pfeffer MA et al. The effect of treatment on survival in congestive heart failure. Clinical Cardiology. 1992;15(5):323-329.
Pitt, B. ; Cohn, J. N. ; Francis, G. S. ; Kostis, J. B. ; Packer, M. ; Pfeffer, M. A. ; Swedberg, K. ; Yusuf, S. / The effect of treatment on survival in congestive heart failure. In: Clinical Cardiology. 1992 ; Vol. 15, No. 5. pp. 323-329.
@article{5e5c6b028150401dbcb58c36434ce917,
title = "The effect of treatment on survival in congestive heart failure",
abstract = "Congestive heart failure (CHF) is a disorder characterized by a variety of clinical, biochemical, electrophysiological, and hemodynamic abnormalities. During the past two decades, numerous drugs have been employed in the treatment of this complex syndrome, and many agents have been shown to improve symptoms and ventricular function in patients with CHF. Because CHF is associated with a high risk of death, treatment should be directed not only toward the relief of symptoms, but also toward a reduction in mortality. Many variables have been shown to be related to survival; taken individually, however, each is limited in its utility in predicting prognosis. In recent years, large-scale studies with large sample sizes have directly assessed the effects of treatment on mortality in CHF. Results from these trials indicate that vasodilators and angiotensin-converting enzyme (ACE) inhibitors may improve mortality in patients with symptoms of heart failure. Additional trials are now in progress to evaluate the effect of treatment on patients with asymptomatic left ventricular dysfunction.",
keywords = "congestive heart failure, drug treatment, mortality, prognosis",
author = "B. Pitt and Cohn, {J. N.} and Francis, {G. S.} and Kostis, {J. B.} and M. Packer and Pfeffer, {M. A.} and K. Swedberg and S. Yusuf",
year = "1992",
language = "English (US)",
volume = "15",
pages = "323--329",
journal = "Clinical Cardiology",
issn = "0160-9289",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - The effect of treatment on survival in congestive heart failure

AU - Pitt, B.

AU - Cohn, J. N.

AU - Francis, G. S.

AU - Kostis, J. B.

AU - Packer, M.

AU - Pfeffer, M. A.

AU - Swedberg, K.

AU - Yusuf, S.

PY - 1992

Y1 - 1992

N2 - Congestive heart failure (CHF) is a disorder characterized by a variety of clinical, biochemical, electrophysiological, and hemodynamic abnormalities. During the past two decades, numerous drugs have been employed in the treatment of this complex syndrome, and many agents have been shown to improve symptoms and ventricular function in patients with CHF. Because CHF is associated with a high risk of death, treatment should be directed not only toward the relief of symptoms, but also toward a reduction in mortality. Many variables have been shown to be related to survival; taken individually, however, each is limited in its utility in predicting prognosis. In recent years, large-scale studies with large sample sizes have directly assessed the effects of treatment on mortality in CHF. Results from these trials indicate that vasodilators and angiotensin-converting enzyme (ACE) inhibitors may improve mortality in patients with symptoms of heart failure. Additional trials are now in progress to evaluate the effect of treatment on patients with asymptomatic left ventricular dysfunction.

AB - Congestive heart failure (CHF) is a disorder characterized by a variety of clinical, biochemical, electrophysiological, and hemodynamic abnormalities. During the past two decades, numerous drugs have been employed in the treatment of this complex syndrome, and many agents have been shown to improve symptoms and ventricular function in patients with CHF. Because CHF is associated with a high risk of death, treatment should be directed not only toward the relief of symptoms, but also toward a reduction in mortality. Many variables have been shown to be related to survival; taken individually, however, each is limited in its utility in predicting prognosis. In recent years, large-scale studies with large sample sizes have directly assessed the effects of treatment on mortality in CHF. Results from these trials indicate that vasodilators and angiotensin-converting enzyme (ACE) inhibitors may improve mortality in patients with symptoms of heart failure. Additional trials are now in progress to evaluate the effect of treatment on patients with asymptomatic left ventricular dysfunction.

KW - congestive heart failure

KW - drug treatment

KW - mortality

KW - prognosis

UR - http://www.scopus.com/inward/record.url?scp=0026659702&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026659702&partnerID=8YFLogxK

M3 - Article

VL - 15

SP - 323

EP - 329

JO - Clinical Cardiology

JF - Clinical Cardiology

SN - 0160-9289

IS - 5

ER -