The effect of treatment with clofibrate on hepatic triglyceride and lipoprotein lipase activities of post heparin plasma in male patients with hyperlipoproteinemia

Jonas Boberg, Merike Boberg, Richard Gross, Scott M Grundy, Jan Augustin, Virgil Brown

Research output: Contribution to journalArticle

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Abstract

Twelve male patients with hyperlipoproteinemia were treated with clofibrate, 1 g twice daily. Serum triglyceride concentration decreased on the average 28 ± 6%. No significant change of serum cholesterol concentration occurred. Post heparin plasma lipoprotein lipase activity isolated and partially purified by heparin Sepharose affinity chromatography was determined quantitatively. During the clofibrate treatment this enzyme activity increased 48 ± 9%. The post heparin hepatic triglyceride lipase did not change significantly. The possibility that the serum triglyceride-lowering effect of clofibrate might partly be explained by an increased removal rate of triglyceride rich lipoproteins through increased lipoprotein lipase activity is discussed.

Original languageEnglish (US)
Pages (from-to)499-503
Number of pages5
JournalAtherosclerosis
Volume27
Issue number4
DOIs
StatePublished - 1977

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Keywords

  • Clofibrate
  • Hepatic triglyceride lipase activity
  • Hyperlipoproteinemia
  • Lipoprotein lipase activity
  • Serum cholesterol
  • Serum triglycerides

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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