The effect of ultraviolet B radiation treatments on calcium excretion and vitamin D metabolites in kidney stone formers

M. Varghese, J. S. Rodman, J. J. Williams, A. Brown, D. M. Carter, J. E. Zerwekh, C. Y C Pak

Research output: Contribution to journalArticle

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Abstract

Several factors could explain the effect of warm, sunny weather on kidney stone formation. To determine the role of sun exposure, we used a light box to administer artificial ultraviolet B radiation during the winter months in New York City. Eleven male stone formers and 7 age- and sex-matched controls received 10 UVB light exposures over a two-week period while maintaining a 400 mg calcium diet. 25-OH vitamin D levels increased significantly (p < 0.001) in both patients (25.9 ± 9.8 to 51.6 ± 14.1 ng/ml) and controls (21.3 ± 7.1 to 49.6 ± 3.1 ng/ml). However, 1,25 dihydroxyvitamin D levels rose in the patients (50.8 ± 14.8 to 55.9 ± 13.1 pg/ml) but fell (60.1 ± 6.5 to 49.4 ± 3.1 pg/ml) in the controls. Only 2 of the 11 patients but all of the controls demonstrated this down regulation of 1,25 dihydroxyvitamin D levels (p < 0.002). 24,25 dihydroxyvitamin D levels tended to rise in both groups but parathyroid hormone levels were unchanged. There was a trend, which did not reach statistical significance, for parameters of calcium excretion to increase after UVB radiation. 24-hour urinary calcium excretion rose 24% from 140 to 173 mg in the patients and 31% from 113 to 148 mg in the controls. The ratio of calcium/creatinine following a one gram calcium load showed a small increase after UVB radiation from 0.17 to 0.20 in patients and 0.118 to 0.124 in the controls. However, no correlation could be discerned between changes in vitamin D metabolite concentrations and changes in urinary calcium. Our data support the notion that regulation of 1,25 dihydroxyvitamin D is different in stone formers but that changes in this metabolite cannot alone account for the phenomenon of absorptive hypercalciuria.

Original languageEnglish (US)
Pages (from-to)225-231
Number of pages7
JournalClinical Nephrology
Volume31
Issue number5
StatePublished - 1989

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Kidney Calculi
Vitamin D
Radiation
Calcium
Therapeutics
Light
Hypercalciuria
Dihydroxycholecalciferols
Weather
Solar System
Parathyroid Hormone
Creatinine
Down-Regulation
Diet
1,25-dihydroxyvitamin D

ASJC Scopus subject areas

  • Nephrology

Cite this

Varghese, M., Rodman, J. S., Williams, J. J., Brown, A., Carter, D. M., Zerwekh, J. E., & Pak, C. Y. C. (1989). The effect of ultraviolet B radiation treatments on calcium excretion and vitamin D metabolites in kidney stone formers. Clinical Nephrology, 31(5), 225-231.

The effect of ultraviolet B radiation treatments on calcium excretion and vitamin D metabolites in kidney stone formers. / Varghese, M.; Rodman, J. S.; Williams, J. J.; Brown, A.; Carter, D. M.; Zerwekh, J. E.; Pak, C. Y C.

In: Clinical Nephrology, Vol. 31, No. 5, 1989, p. 225-231.

Research output: Contribution to journalArticle

Varghese, M, Rodman, JS, Williams, JJ, Brown, A, Carter, DM, Zerwekh, JE & Pak, CYC 1989, 'The effect of ultraviolet B radiation treatments on calcium excretion and vitamin D metabolites in kidney stone formers', Clinical Nephrology, vol. 31, no. 5, pp. 225-231.
Varghese M, Rodman JS, Williams JJ, Brown A, Carter DM, Zerwekh JE et al. The effect of ultraviolet B radiation treatments on calcium excretion and vitamin D metabolites in kidney stone formers. Clinical Nephrology. 1989;31(5):225-231.
Varghese, M. ; Rodman, J. S. ; Williams, J. J. ; Brown, A. ; Carter, D. M. ; Zerwekh, J. E. ; Pak, C. Y C. / The effect of ultraviolet B radiation treatments on calcium excretion and vitamin D metabolites in kidney stone formers. In: Clinical Nephrology. 1989 ; Vol. 31, No. 5. pp. 225-231.
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abstract = "Several factors could explain the effect of warm, sunny weather on kidney stone formation. To determine the role of sun exposure, we used a light box to administer artificial ultraviolet B radiation during the winter months in New York City. Eleven male stone formers and 7 age- and sex-matched controls received 10 UVB light exposures over a two-week period while maintaining a 400 mg calcium diet. 25-OH vitamin D levels increased significantly (p < 0.001) in both patients (25.9 ± 9.8 to 51.6 ± 14.1 ng/ml) and controls (21.3 ± 7.1 to 49.6 ± 3.1 ng/ml). However, 1,25 dihydroxyvitamin D levels rose in the patients (50.8 ± 14.8 to 55.9 ± 13.1 pg/ml) but fell (60.1 ± 6.5 to 49.4 ± 3.1 pg/ml) in the controls. Only 2 of the 11 patients but all of the controls demonstrated this down regulation of 1,25 dihydroxyvitamin D levels (p < 0.002). 24,25 dihydroxyvitamin D levels tended to rise in both groups but parathyroid hormone levels were unchanged. There was a trend, which did not reach statistical significance, for parameters of calcium excretion to increase after UVB radiation. 24-hour urinary calcium excretion rose 24{\%} from 140 to 173 mg in the patients and 31{\%} from 113 to 148 mg in the controls. The ratio of calcium/creatinine following a one gram calcium load showed a small increase after UVB radiation from 0.17 to 0.20 in patients and 0.118 to 0.124 in the controls. However, no correlation could be discerned between changes in vitamin D metabolite concentrations and changes in urinary calcium. Our data support the notion that regulation of 1,25 dihydroxyvitamin D is different in stone formers but that changes in this metabolite cannot alone account for the phenomenon of absorptive hypercalciuria.",
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