The effect of vitamin D on falls

A systematic review and meta-analysis

Mohammad Hassan Murad, Khalid B. Elamin, Nisrin O. Abu Elnour, Mohamed B. Elamin, Aziz A. Alkatib, Mitra M. Fatourechi, Jaime P. Almandoz, Rebecca J. Mullan, Melanie A. Lane, Hau Liu, Patricia J. Erwin, Donald D. Hensrud, Victor M. Montori

Research output: Contribution to journalArticle

250 Citations (Scopus)

Abstract

Context: Vitamin D affects bone and muscle health and likely reduces the risk of falls in the elderly. Objective: The aim of this systematic review is to summarize the existing evidence on vitamin D use and the risk of falls. Data Sources: We searched electronic databases from inception through August 2010. Study Selection: Eligible studies were randomized controlled trials in which the intervention was vitamin D and the incidence of falls was reported. Data Extraction: Reviewers working in duplicate and independently extracted study characteristics, quality, and outcomes data. Data Synthesis: Odds ratio and associated 95% confidence interval were estimated from each study and pooled using the random effects model. Results: We found 26 eligible trials of moderate quality that enrolled 45,782 participants, the majority of which were elderly and female. Vitamin D use was associated with statistically significant reduction in the risk of falls (odds ratio for suffering at least one fall, 0.86; 95% confidence interval, 0.77-0.96). This effect was more prominent in patients who were vitamin D deficient at baseline and in studies in which calcium was coadministered with vitamin D. The quality of evidence was low to moderate because of heterogeneity and publication bias. Conclusions: Vitamin D combined with calcium reduces the risk of falls. The reduction in studies without calcium coadministration did not reach statistical significance. The majority of the evidence is derived from trials enrolling elderly women.

Original languageEnglish (US)
Pages (from-to)2997-3006
Number of pages10
JournalJournal of Clinical Endocrinology and Metabolism
Volume96
Issue number10
DOIs
StatePublished - Oct 2011

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Vitamin D
Meta-Analysis
Calcium
Odds Ratio
Confidence Intervals
Publication Bias
Information Storage and Retrieval
Risk Reduction Behavior
Muscle
Bone
Randomized Controlled Trials
Health
Databases
Bone and Bones
Muscles
Incidence

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Murad, M. H., Elamin, K. B., Abu Elnour, N. O., Elamin, M. B., Alkatib, A. A., Fatourechi, M. M., ... Montori, V. M. (2011). The effect of vitamin D on falls: A systematic review and meta-analysis. Journal of Clinical Endocrinology and Metabolism, 96(10), 2997-3006. https://doi.org/10.1210/jc.2011-1193

The effect of vitamin D on falls : A systematic review and meta-analysis. / Murad, Mohammad Hassan; Elamin, Khalid B.; Abu Elnour, Nisrin O.; Elamin, Mohamed B.; Alkatib, Aziz A.; Fatourechi, Mitra M.; Almandoz, Jaime P.; Mullan, Rebecca J.; Lane, Melanie A.; Liu, Hau; Erwin, Patricia J.; Hensrud, Donald D.; Montori, Victor M.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 96, No. 10, 10.2011, p. 2997-3006.

Research output: Contribution to journalArticle

Murad, MH, Elamin, KB, Abu Elnour, NO, Elamin, MB, Alkatib, AA, Fatourechi, MM, Almandoz, JP, Mullan, RJ, Lane, MA, Liu, H, Erwin, PJ, Hensrud, DD & Montori, VM 2011, 'The effect of vitamin D on falls: A systematic review and meta-analysis', Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 10, pp. 2997-3006. https://doi.org/10.1210/jc.2011-1193
Murad MH, Elamin KB, Abu Elnour NO, Elamin MB, Alkatib AA, Fatourechi MM et al. The effect of vitamin D on falls: A systematic review and meta-analysis. Journal of Clinical Endocrinology and Metabolism. 2011 Oct;96(10):2997-3006. https://doi.org/10.1210/jc.2011-1193
Murad, Mohammad Hassan ; Elamin, Khalid B. ; Abu Elnour, Nisrin O. ; Elamin, Mohamed B. ; Alkatib, Aziz A. ; Fatourechi, Mitra M. ; Almandoz, Jaime P. ; Mullan, Rebecca J. ; Lane, Melanie A. ; Liu, Hau ; Erwin, Patricia J. ; Hensrud, Donald D. ; Montori, Victor M. / The effect of vitamin D on falls : A systematic review and meta-analysis. In: Journal of Clinical Endocrinology and Metabolism. 2011 ; Vol. 96, No. 10. pp. 2997-3006.
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