The effects of alphavirus infection on neurons

Diane E. Griffin, Beth Levine, Sukathida Ubol, J. Marie Hardwick

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Sindbis virus is an alphavirus that causes encephalitis in mice. The primary target cells for central nervous system infection are neurons. The outcome of neuronal infection is dependent on the age of the mouse at the time of infection (maturity of the neuron) and the strain of virus used for infection (virulence of the virus). Sindbis virus causes neuronal death by inducing apoptosis. As neurons mature, they become resistant to virus- induced apoptosis, resulting in a persistent infection. Host production of antibody to a viral surface glycoprotein acts to downregulate virus replication in the infected neurons by a noncytolytic mechanism and clears infectious virus from the central nervous system. Specific genetic changes in the virus result in more virulent strains that cause severe disease and sometimes death in mature animals. These same genetic alterations also confer the ability to overcome the resistance of neurons to induction of cell death. Therefore, mature neurons infected with virulent viruses do not recover from infection even in the presence of an adequate immune response.

Original languageEnglish (US)
JournalAnnals of Neurology
Volume35
Issue numberSUPPL.
DOIs
StatePublished - 1994

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Alphavirus Infections
Neurons
Viruses
Sindbis Virus
Infection
Apoptosis
Alphavirus
Central Nervous System Infections
Membrane Glycoproteins
Virus Diseases
Encephalitis
Virus Replication
Antibody Formation
Virulence
Cause of Death
Cell Death
Down-Regulation
Central Nervous System

ASJC Scopus subject areas

  • Neuroscience(all)

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The effects of alphavirus infection on neurons. / Griffin, Diane E.; Levine, Beth; Ubol, Sukathida; Hardwick, J. Marie.

In: Annals of Neurology, Vol. 35, No. SUPPL., 1994.

Research output: Contribution to journalArticle

Griffin, Diane E. ; Levine, Beth ; Ubol, Sukathida ; Hardwick, J. Marie. / The effects of alphavirus infection on neurons. In: Annals of Neurology. 1994 ; Vol. 35, No. SUPPL.
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