The effects of CoCl2 on glucagon levels in plasma and pancreas of the rat

J. de V Lochner, Anne M. Eisentraut, Roger H Unger

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Fed, male adult rats were given an i.p. injection of CoCl2 (25 mg./Kg.) after pretreatment with nicotinamide (750 mg./Kg.) to reduce the mortality rate. A trasient hyperglycemic phase was observed during the first hour after the injection and was accompanied by a significant increase in plasma glucagon levels, suggesting that the hyperglycemia may be due to a release of glucagon from the alpha cells. No evidence of significant depletion of pancreatic glucagon was observed during the 3 days after treatment nor did glucagon levels decline significantly at any time. It is suggested that, in the rat, CoCl2 is more "alphacytotropic" than "alphacytotoxic" in its action and is ineffective in inducing even a temporary glucagon deficiency.

Original languageEnglish (US)
Pages (from-to)868-874
Number of pages7
Issue number9
StatePublished - Sep 1964

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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