The effects of congenital hypothyroidism using the hyt/hyt mouse on locomotor activity and learned behavior

Amy Anthony, Perrie M. Adams, Stuart A. Stein

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

The offspring of matings between hyt/hyt male mice and hyt/+ females were examined for somatic and behavioral differences. The hyt/hyt offspring displayed delayed somatic development for eye opening and ear extension relative to their euthyroid littermates. Behavioral measurement of locomotor activity indicated hyperactivity at 14 days of age and hypoactivity at 21 and 40 days relative to the euthyroid mice. Impaired swimming escape behavior and Morris maze spatial learning were observed in the hyt/hyt animals. Comparative evaluation of +/+ progenitor strain offspring having no hypothyroidism in their genetic background indicated significant differences in somatic and behavioral endpoints between the hyt/hyt and cuthyroid (hyt/+, +/+) animals. These results confirm tile utility of the hyt/hyt mouse for studies of the impact of congenital hypothyroidism on the functional development of the offspring.

Original languageEnglish (US)
Pages (from-to)418-433
Number of pages16
JournalHormones and Behavior
Volume27
Issue number3
DOIs
StatePublished - Sep 1993

ASJC Scopus subject areas

  • Endocrinology
  • Endocrine and Autonomic Systems
  • Behavioral Neuroscience

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