TY - JOUR
T1 - The effects of dutasteride, tamsulosin, and the combination on storage and voiding in men with benign prostatic hyperplasia and prostatic enlargement
T2 - 2-year results from the Combination of Avodart and Tamsulosin study
AU - Becher, E.
AU - Roehrborn, Claus
AU - Siami, P.
AU - Gagnier, R. P.
AU - Wilson, T. H.
AU - Montorsi, F.
N1 - Funding Information:
This study was funded by GlaxoSmithKline. Medical writing assistance in the preparation of this paper was provided by K Carpenter and funded by GlaxoSmithKline.
PY - 2009
Y1 - 2009
N2 - This article reports the results of a post hoc analysis of the multicenter, randomized, double-blind Combination of Avodart and Tamsulosin (CombAT) study, which aimed to investigate the effects of dutasteride (0.5 mg), tamsulosin (0.4 mg), and their combination on storage and voiding symptoms in 4844 men aged ≥ 50 years with moderate-to-severe lower urinary tract symptoms (International Prostate Symptom Score ≥ 12), prostate volume (PV) ≥ 30 cm3 and PSA 1.5-10 ng ml-1. After 24 months, combination treatment achieved significantly greater mean reductions in both voiding and storage symptoms than either monotherapy, in each of the three baseline PV tertiles (30 to < 42, 42 to < 58, ≥ 58 cm3). Dutasteride was as effective as tamsulosin for control of storage symptoms, but provided significantly greater relief of voiding symptoms than tamsulosin.
AB - This article reports the results of a post hoc analysis of the multicenter, randomized, double-blind Combination of Avodart and Tamsulosin (CombAT) study, which aimed to investigate the effects of dutasteride (0.5 mg), tamsulosin (0.4 mg), and their combination on storage and voiding symptoms in 4844 men aged ≥ 50 years with moderate-to-severe lower urinary tract symptoms (International Prostate Symptom Score ≥ 12), prostate volume (PV) ≥ 30 cm3 and PSA 1.5-10 ng ml-1. After 24 months, combination treatment achieved significantly greater mean reductions in both voiding and storage symptoms than either monotherapy, in each of the three baseline PV tertiles (30 to < 42, 42 to < 58, ≥ 58 cm3). Dutasteride was as effective as tamsulosin for control of storage symptoms, but provided significantly greater relief of voiding symptoms than tamsulosin.
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U2 - 10.1038/pcan.2009.37
DO - 10.1038/pcan.2009.37
M3 - Article
C2 - 19901936
AN - SCOPUS:70649104748
SN - 1365-7852
VL - 12
SP - 369
EP - 374
JO - Prostate Cancer and Prostatic Diseases
JF - Prostate Cancer and Prostatic Diseases
IS - 4
ER -