The effects of dutasteride, tamsulosin, and the combination on storage and voiding in men with benign prostatic hyperplasia and prostatic enlargement: 2-year results from the Combination of Avodart and Tamsulosin study

E. Becher, Claus Roehrborn, P. Siami, R. P. Gagnier, T. H. Wilson, F. Montorsi

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

This article reports the results of a post hoc analysis of the multicenter, randomized, double-blind Combination of Avodart and Tamsulosin (CombAT) study, which aimed to investigate the effects of dutasteride (0.5 mg), tamsulosin (0.4 mg), and their combination on storage and voiding symptoms in 4844 men aged ≥ 50 years with moderate-to-severe lower urinary tract symptoms (International Prostate Symptom Score ≥ 12), prostate volume (PV) ≥ 30 cm3 and PSA 1.5-10 ng ml-1. After 24 months, combination treatment achieved significantly greater mean reductions in both voiding and storage symptoms than either monotherapy, in each of the three baseline PV tertiles (30 to < 42, 42 to < 58, ≥ 58 cm3). Dutasteride was as effective as tamsulosin for control of storage symptoms, but provided significantly greater relief of voiding symptoms than tamsulosin.

Original languageEnglish (US)
Pages (from-to)369-374
Number of pages6
JournalProstate Cancer and Prostatic Diseases
Volume12
Issue number4
DOIs
StatePublished - 2009

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tamsulosin
Prostatic Hyperplasia
Prostate
Lower Urinary Tract Symptoms
Dutasteride

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research

Cite this

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title = "The effects of dutasteride, tamsulosin, and the combination on storage and voiding in men with benign prostatic hyperplasia and prostatic enlargement: 2-year results from the Combination of Avodart and Tamsulosin study",
abstract = "This article reports the results of a post hoc analysis of the multicenter, randomized, double-blind Combination of Avodart and Tamsulosin (CombAT) study, which aimed to investigate the effects of dutasteride (0.5 mg), tamsulosin (0.4 mg), and their combination on storage and voiding symptoms in 4844 men aged ≥ 50 years with moderate-to-severe lower urinary tract symptoms (International Prostate Symptom Score ≥ 12), prostate volume (PV) ≥ 30 cm3 and PSA 1.5-10 ng ml-1. After 24 months, combination treatment achieved significantly greater mean reductions in both voiding and storage symptoms than either monotherapy, in each of the three baseline PV tertiles (30 to < 42, 42 to < 58, ≥ 58 cm3). Dutasteride was as effective as tamsulosin for control of storage symptoms, but provided significantly greater relief of voiding symptoms than tamsulosin.",
author = "E. Becher and Claus Roehrborn and P. Siami and Gagnier, {R. P.} and Wilson, {T. H.} and F. Montorsi",
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T1 - The effects of dutasteride, tamsulosin, and the combination on storage and voiding in men with benign prostatic hyperplasia and prostatic enlargement

T2 - 2-year results from the Combination of Avodart and Tamsulosin study

AU - Becher, E.

AU - Roehrborn, Claus

AU - Siami, P.

AU - Gagnier, R. P.

AU - Wilson, T. H.

AU - Montorsi, F.

PY - 2009

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N2 - This article reports the results of a post hoc analysis of the multicenter, randomized, double-blind Combination of Avodart and Tamsulosin (CombAT) study, which aimed to investigate the effects of dutasteride (0.5 mg), tamsulosin (0.4 mg), and their combination on storage and voiding symptoms in 4844 men aged ≥ 50 years with moderate-to-severe lower urinary tract symptoms (International Prostate Symptom Score ≥ 12), prostate volume (PV) ≥ 30 cm3 and PSA 1.5-10 ng ml-1. After 24 months, combination treatment achieved significantly greater mean reductions in both voiding and storage symptoms than either monotherapy, in each of the three baseline PV tertiles (30 to < 42, 42 to < 58, ≥ 58 cm3). Dutasteride was as effective as tamsulosin for control of storage symptoms, but provided significantly greater relief of voiding symptoms than tamsulosin.

AB - This article reports the results of a post hoc analysis of the multicenter, randomized, double-blind Combination of Avodart and Tamsulosin (CombAT) study, which aimed to investigate the effects of dutasteride (0.5 mg), tamsulosin (0.4 mg), and their combination on storage and voiding symptoms in 4844 men aged ≥ 50 years with moderate-to-severe lower urinary tract symptoms (International Prostate Symptom Score ≥ 12), prostate volume (PV) ≥ 30 cm3 and PSA 1.5-10 ng ml-1. After 24 months, combination treatment achieved significantly greater mean reductions in both voiding and storage symptoms than either monotherapy, in each of the three baseline PV tertiles (30 to < 42, 42 to < 58, ≥ 58 cm3). Dutasteride was as effective as tamsulosin for control of storage symptoms, but provided significantly greater relief of voiding symptoms than tamsulosin.

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