The effects of fluoxetine on the polysomnogram of depressed outpatients: A pilot study

William A. Hendrickse, Howard P. Roffwarg, Bruce D. Grannemann, Paul J. Orsulak, Roseanne Armitage, John W. Cain, John Battaglia, John R. Debus, A. John Rush

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

The effects of fluoxetine (FLU) and its active metabolite, norfluoxetine (NFLU), on the polysomnogram (PSG) of nine depressed outpatients (eight with major depression; one with bipolar II, depressed phase disorder) were investigated by contrasting PSG values prior to treatment and during administration of FLU. The PSG changes were correlated with daily dose, cumulative dosage, single serum concentrations, and the total area under the serum concentration curve (AUC) of both FLU and NFLU. Fluoxetine clearly increased both stage 1 sleep time and rapid-eye-movement (REM) latency and decreased both percent REM and REM density. With a few exceptions, the cumulative dosage of FLU and the AUC of FLU and NFLU were better predictors of the changes in awake and movement time in the PSG than single-sample concentrations of FLU and NFLU taken at the time of PSG assessment.

Original languageEnglish (US)
Pages (from-to)85-91
Number of pages7
JournalNeuropsychopharmacology
Volume10
Issue number2
DOIs
StatePublished - Apr 1994

Keywords

  • Depression
  • Fluoxetine
  • Norfluoxetine
  • Polysomnography
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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    Hendrickse, W. A., Roffwarg, H. P., Grannemann, B. D., Orsulak, P. J., Armitage, R., Cain, J. W., Battaglia, J., Debus, J. R., & Rush, A. J. (1994). The effects of fluoxetine on the polysomnogram of depressed outpatients: A pilot study. Neuropsychopharmacology, 10(2), 85-91. https://doi.org/10.1038/npp.1994.10