The effects of fluoxetine on the polysomnogram of depressed outpatients: A pilot study

William A. Hendrickse, Howard P. Roffwarg, Bruce D. Grannemann, Paul J. Orsulak, Roseanne Armitage, John W. Cain, John Battaglia, John R. Debus, A. John Rush

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

The effects of fluoxetine (FLU) and its active metabolite, norfluoxetine (NFLU), on the polysomnogram (PSG) of nine depressed outpatients (eight with major depression; one with bipolar II, depressed phase disorder) were investigated by contrasting PSG values prior to treatment and during administration of FLU. The PSG changes were correlated with daily dose, cumulative dosage, single serum concentrations, and the total area under the serum concentration curve (AUC) of both FLU and NFLU. Fluoxetine clearly increased both stage 1 sleep time and rapid-eye-movement (REM) latency and decreased both percent REM and REM density. With a few exceptions, the cumulative dosage of FLU and the AUC of FLU and NFLU were better predictors of the changes in awake and movement time in the PSG than single-sample concentrations of FLU and NFLU taken at the time of PSG assessment.

Original languageEnglish (US)
Pages (from-to)85-91
Number of pages7
JournalNeuropsychopharmacology
Volume10
Issue number2
StatePublished - 1994

Fingerprint

Fluoxetine
Outpatients
REM Sleep
Area Under Curve
Sleep Stages
Serum
Depression
norfluoxetine

Keywords

  • Depression
  • Fluoxetine
  • Norfluoxetine
  • Polysomnography
  • Serotonin

ASJC Scopus subject areas

  • Pharmacology

Cite this

Hendrickse, W. A., Roffwarg, H. P., Grannemann, B. D., Orsulak, P. J., Armitage, R., Cain, J. W., ... Rush, A. J. (1994). The effects of fluoxetine on the polysomnogram of depressed outpatients: A pilot study. Neuropsychopharmacology, 10(2), 85-91.

The effects of fluoxetine on the polysomnogram of depressed outpatients : A pilot study. / Hendrickse, William A.; Roffwarg, Howard P.; Grannemann, Bruce D.; Orsulak, Paul J.; Armitage, Roseanne; Cain, John W.; Battaglia, John; Debus, John R.; Rush, A. John.

In: Neuropsychopharmacology, Vol. 10, No. 2, 1994, p. 85-91.

Research output: Contribution to journalArticle

Hendrickse, WA, Roffwarg, HP, Grannemann, BD, Orsulak, PJ, Armitage, R, Cain, JW, Battaglia, J, Debus, JR & Rush, AJ 1994, 'The effects of fluoxetine on the polysomnogram of depressed outpatients: A pilot study', Neuropsychopharmacology, vol. 10, no. 2, pp. 85-91.
Hendrickse WA, Roffwarg HP, Grannemann BD, Orsulak PJ, Armitage R, Cain JW et al. The effects of fluoxetine on the polysomnogram of depressed outpatients: A pilot study. Neuropsychopharmacology. 1994;10(2):85-91.
Hendrickse, William A. ; Roffwarg, Howard P. ; Grannemann, Bruce D. ; Orsulak, Paul J. ; Armitage, Roseanne ; Cain, John W. ; Battaglia, John ; Debus, John R. ; Rush, A. John. / The effects of fluoxetine on the polysomnogram of depressed outpatients : A pilot study. In: Neuropsychopharmacology. 1994 ; Vol. 10, No. 2. pp. 85-91.
@article{d561a29bb9b1477ea3914cbd357c83ef,
title = "The effects of fluoxetine on the polysomnogram of depressed outpatients: A pilot study",
abstract = "The effects of fluoxetine (FLU) and its active metabolite, norfluoxetine (NFLU), on the polysomnogram (PSG) of nine depressed outpatients (eight with major depression; one with bipolar II, depressed phase disorder) were investigated by contrasting PSG values prior to treatment and during administration of FLU. The PSG changes were correlated with daily dose, cumulative dosage, single serum concentrations, and the total area under the serum concentration curve (AUC) of both FLU and NFLU. Fluoxetine clearly increased both stage 1 sleep time and rapid-eye-movement (REM) latency and decreased both percent REM and REM density. With a few exceptions, the cumulative dosage of FLU and the AUC of FLU and NFLU were better predictors of the changes in awake and movement time in the PSG than single-sample concentrations of FLU and NFLU taken at the time of PSG assessment.",
keywords = "Depression, Fluoxetine, Norfluoxetine, Polysomnography, Serotonin",
author = "Hendrickse, {William A.} and Roffwarg, {Howard P.} and Grannemann, {Bruce D.} and Orsulak, {Paul J.} and Roseanne Armitage and Cain, {John W.} and John Battaglia and Debus, {John R.} and Rush, {A. John}",
year = "1994",
language = "English (US)",
volume = "10",
pages = "85--91",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - The effects of fluoxetine on the polysomnogram of depressed outpatients

T2 - A pilot study

AU - Hendrickse, William A.

AU - Roffwarg, Howard P.

AU - Grannemann, Bruce D.

AU - Orsulak, Paul J.

AU - Armitage, Roseanne

AU - Cain, John W.

AU - Battaglia, John

AU - Debus, John R.

AU - Rush, A. John

PY - 1994

Y1 - 1994

N2 - The effects of fluoxetine (FLU) and its active metabolite, norfluoxetine (NFLU), on the polysomnogram (PSG) of nine depressed outpatients (eight with major depression; one with bipolar II, depressed phase disorder) were investigated by contrasting PSG values prior to treatment and during administration of FLU. The PSG changes were correlated with daily dose, cumulative dosage, single serum concentrations, and the total area under the serum concentration curve (AUC) of both FLU and NFLU. Fluoxetine clearly increased both stage 1 sleep time and rapid-eye-movement (REM) latency and decreased both percent REM and REM density. With a few exceptions, the cumulative dosage of FLU and the AUC of FLU and NFLU were better predictors of the changes in awake and movement time in the PSG than single-sample concentrations of FLU and NFLU taken at the time of PSG assessment.

AB - The effects of fluoxetine (FLU) and its active metabolite, norfluoxetine (NFLU), on the polysomnogram (PSG) of nine depressed outpatients (eight with major depression; one with bipolar II, depressed phase disorder) were investigated by contrasting PSG values prior to treatment and during administration of FLU. The PSG changes were correlated with daily dose, cumulative dosage, single serum concentrations, and the total area under the serum concentration curve (AUC) of both FLU and NFLU. Fluoxetine clearly increased both stage 1 sleep time and rapid-eye-movement (REM) latency and decreased both percent REM and REM density. With a few exceptions, the cumulative dosage of FLU and the AUC of FLU and NFLU were better predictors of the changes in awake and movement time in the PSG than single-sample concentrations of FLU and NFLU taken at the time of PSG assessment.

KW - Depression

KW - Fluoxetine

KW - Norfluoxetine

KW - Polysomnography

KW - Serotonin

UR - http://www.scopus.com/inward/record.url?scp=0028176833&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028176833&partnerID=8YFLogxK

M3 - Article

C2 - 8024676

AN - SCOPUS:0028176833

VL - 10

SP - 85

EP - 91

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

IS - 2

ER -