The effects of natalizumab on the innate and adaptive immune system in the central nervous system

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Abstract

Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system (CNS). Natalizumab (®Tysabri) is a humanized recombinant monoclonal antibody that binds to the alpha (α)4 chain of the α4 beta (β)1 integrin (very late activation antigen 4; VLA-4), and α4β7 integrin. Recently, two patients with MS and one patient with Crohn's disease who were treated with natalizumab in the setting of clinical trials developed progressive multifocal leukoencephalopathy (PML), an opportunistic infection of the brain with the polyoma virus JC. We recently showed that natalizumab decreases the numbers of CD4+ and CD8+ T lymphocytes, CD19+ B cells, and CD138+ plasma cells in the cerebrospinal fluid (CSF) of patients with MS on natalizumab therapy. In addition, we demonstrated that the cell numbers in CSF remained unchanged even 6 months after cessation of natalizumab treatment.

Original languageEnglish (US)
Pages (from-to)39-41
Number of pages3
JournalJournal of the Neurological Sciences
Volume274
Issue number1-2
DOIs
Publication statusPublished - Nov 15 2008

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Keywords

  • Antigen presentation
  • Brain
  • Crohn's disease
  • Immunosuppression
  • Inflammatory bowel disease
  • Integrin
  • JC virus
  • Natalizumab
  • Perivascular spaces
  • Pharmacotherapy
  • PML
  • Polyoma virus
  • Progressive multifocal leukoencephalopathy
  • Tysabri
  • Virchow Robin space

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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