The effects of reduced end-tidal carbon dioxide tension on cerebral blood flow during heat stress

R. Matthew Brothers, Jonathan E. Wingo, Kimberly A. Hubing, Craig G. Crandall

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Passive heat stress reduces arterial carbon dioxide partial pressure (PaCO2) as reflected by 3 to 5 Torr reductions in end-tidal carbon dioxide tension (PETCO2). Heat stress also reduces cerebrovascular conductance (CBVC) by up to 30%. While is a strong regulator of CBVC, it is unlikely that the relatively small change in during heating is solely responsible for the reductions in CBVC. This study tested the hypothesis that, referenced by, is not the sole mechanism for reductions in CBVC during heat stress. Mean arterial blood pressure (MAP) PETCO2, middle cerebral artery blood velocity (MCA Vmean), and calculated CBVC (MCA Vmean/MAP) were assessed in seven healthy individuals, during three separate conditions performed sequentially: (1) normothemia, (2) control passive heat stress and (3) passive heat stress with clamped at the normothermic level (using a computer-controlled sequential gas delivery breathing circuit). MAP was similar in the three thermal conditions (P = 0.55). Control heat stress increased internal temperature ∼1.3°C, which resulted in decreases in, MCA Vmean and calculated CBVC (P < 0.001 for all variables). During heat stress + clamp conditions internal temperature remained similar to that during the control heat stress condition (P = 0.31). Heat stress + clamp successfully restored PETCO2 to the normothermic level (P = 0.99) and increased MCA V mean (P = 0.002) and CBVC (P = 0.008) relative to control heat stress. Despite restoration of, MCA Vmean (P = 0.005) and CBVC (P = 0.03) remained reduced relative to normothermia. These results indicate that heat stress-induced reductions in PaCO2, as referenced by, contribute to the decrease in MCA Vmean and CBVC; however, other factors (e.g. perhaps elevated sympathetic nerve activity) are also involved in mediating this response.

Original languageEnglish (US)
Pages (from-to)3921-3927
Number of pages7
JournalJournal of Physiology
Volume587
Issue number15
DOIs
StatePublished - Aug 10 2009

ASJC Scopus subject areas

  • Physiology

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