The effects of restraint stress on the neuropathogenesis of theiler's virus-induced demyelination: A murine model for multiple sclerosis

C. Jane Welsh, Mi Wentao, Amy Sieve, Andrew Steelman, Robin R. Johnson, Colin R. Young, Thomas Prentice, Ashley Hammons, Ralph Storts, Thomas Welsh, Mary W. Meagher

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Physical and psychosocial stressors have been shown to compromise immune function (Ader et al., 1991; Kielcolt-Glaser and Glaser, 1995). The immune suppressive effects of stress may be more pronounced in individuals that already have limited immune competence, such as infants, individuals with a predisposition to autoimmune disease, and the elderly (Kielcolt-Glaser and Glaser, 1995). An individual's response to a stressor is manifested in physiological, hormonal, behavioral, and immunological changes. These stress-induced responses are initiated by the hypothalamus and translated into action by the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system. Products from these two systems (e.g., corticoid hormones and catecholamines) can directly modulate the activity of various immune effector cells (Ader et al., 1991).

Original languageEnglish (US)
Title of host publicationNeural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity
PublisherSpringer US
Pages190-215
Number of pages26
ISBN (Print)0387314113, 9780387314112
DOIs
StatePublished - 2006

ASJC Scopus subject areas

  • Neuroscience(all)

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    Welsh, C. J., Wentao, M., Sieve, A., Steelman, A., Johnson, R. R., Young, C. R., Prentice, T., Hammons, A., Storts, R., Welsh, T., & Meagher, M. W. (2006). The effects of restraint stress on the neuropathogenesis of theiler's virus-induced demyelination: A murine model for multiple sclerosis. In Neural and Neuroendocrine Mechanisms in Host Defense and Autoimmunity (pp. 190-215). Springer US. https://doi.org/10.1007/978-0-387-48334-4_10