The Effects of TGF-β3 Modulation on Scar Tissue Formation in the Pig

Nathan D. Schwade, James J. Fowler, Joseph Leach

Research output: Contribution to journalArticle

Abstract

Transforming growth factor beta (TGF-β) is a product of platelets, macrophages and fibroblasts that is instrumental in modulating the healing process. Of the three distinct subtypes of TGF-β present in humans, TGF-β3 has been noted to reduce cutaneous scarring in rats. In an effort to investigate the effects of TGF-β3 on skin more closely resembling that of humans, TGF-β3 and its antibody were injected serially into porcine cutaneous wounds. Exogenous administration of antibody to TGF-β3 significantly increases the breaking strength of porcine wounds seven and fourteen days post injury. A significant elevation in the breaking strength of wounds treated with higher doses of TGF-β3 antibody at seven and fourteen days post injury was noted compared to controls. Histologic examination revealed substantially greater fibroplasia in the dermis of wounds treated with higher doses of antibody to TGF-β3 fourteen days post injury when compared to control. Exogenous administration of antibody to TGF-β3 significantly increases the breaking strength of porcine wounds seven and fourteen days post injury.

Original languageEnglish (US)
Pages (from-to)32-39
Number of pages8
JournalWounds
Volume12
Issue number2
Publication statusPublished - Mar 2000

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ASJC Scopus subject areas

  • Surgery

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