TY - JOUR
T1 - The efficacy of coronary sinus reducer in patients with refractory angina—A systematic review of the literature
AU - Bazoukis, George
AU - Brilakis, Emmanouil S.
AU - Tse, Gary
AU - Letsas, Konstantinos P.
AU - Kitsoulis, Panagiotis
AU - Liu, Tong
AU - Baranchuk, Adrian
AU - Sideris, Antonios
AU - Tsioufis, Costas
AU - Stavrakis, Stavros
N1 - Publisher Copyright:
© 2018 Wiley Periodicals, Inc.
PY - 2018/12
Y1 - 2018/12
N2 - Objectives: The aim of our systematic review was to investigate the efficacy of coronary sinus (CS) reducer device in patients with refractory angina. Background: The CS reducer device provides a therapeutic option for patients with coronary artery disease who are not suitable for revascularization. Methods: Two independent investigators (GB and GT) systematically searched the Medline and Cochrane library databases for studies describing the efficacy and safety of the CS reducer in patients with refractory angina from January 1, 2000 until May 12, 2018 using the following terms: “coronary sinus (reducer OR reducing) device.” Efficacy was defined as ≥1 unit improvement in the Canadian cardiovascular society (CCS) score. Results: Our search strategy provided six studies (five observational studies and one randomized clinical trial) with 196 patients. The CS reducer device was effective in 146/186 (78.5%) patients. CCS score improved from 3.2 at baseline to 1.9 after 8.6 months of follow-up. The efficacy of CS reducer device was also demonstrated as an improvement in Seattle Angina Questionnaire score, dobutamine echocardiography, thalium single-photon emission computed tomography perfusion studies, 6-min-walk test and myocardial perfusion reserve index. Implantation failed in 4 of 196 (2%) patients and 5 patients (2.5%) had a complication during 30-day follow-up. Conclusions: The CS reducer is a promising treatment option for patients with refractory angina who are not candidates for revascularization. However, larger randomized control trials with long-term follow-up are needed to elucidate its role.
AB - Objectives: The aim of our systematic review was to investigate the efficacy of coronary sinus (CS) reducer device in patients with refractory angina. Background: The CS reducer device provides a therapeutic option for patients with coronary artery disease who are not suitable for revascularization. Methods: Two independent investigators (GB and GT) systematically searched the Medline and Cochrane library databases for studies describing the efficacy and safety of the CS reducer in patients with refractory angina from January 1, 2000 until May 12, 2018 using the following terms: “coronary sinus (reducer OR reducing) device.” Efficacy was defined as ≥1 unit improvement in the Canadian cardiovascular society (CCS) score. Results: Our search strategy provided six studies (five observational studies and one randomized clinical trial) with 196 patients. The CS reducer device was effective in 146/186 (78.5%) patients. CCS score improved from 3.2 at baseline to 1.9 after 8.6 months of follow-up. The efficacy of CS reducer device was also demonstrated as an improvement in Seattle Angina Questionnaire score, dobutamine echocardiography, thalium single-photon emission computed tomography perfusion studies, 6-min-walk test and myocardial perfusion reserve index. Implantation failed in 4 of 196 (2%) patients and 5 patients (2.5%) had a complication during 30-day follow-up. Conclusions: The CS reducer is a promising treatment option for patients with refractory angina who are not candidates for revascularization. However, larger randomized control trials with long-term follow-up are needed to elucidate its role.
KW - coronary artery disease
KW - coronary sinus reducer device
KW - refractory angina
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U2 - 10.1111/joic.12560
DO - 10.1111/joic.12560
M3 - Review article
C2 - 30191622
AN - SCOPUS:85052926571
SN - 0896-4327
VL - 31
SP - 775
EP - 779
JO - Journal of Interventional Cardiology
JF - Journal of Interventional Cardiology
IS - 6
ER -