The efficacy of diphtheria-growth factor fusion proteins is enhanced by co-administration of cytosine arabinoside in an immunodeficient mouse model of human acute myeloid leukemia

Donna E. Hogge; Michaela Feuring-Buske; Brigitte Gerhard; Arthur E. Frankel

doi:10.1016/j.leukres.2004.03.015

The efficacy of diphtheria-growth factor fusion proteins is enhanced by co-administration of cytosine arabinoside in an immunodeficient mouse model of human acute myeloid leukemia

Donna E. Hogge, Michaela Feuring-Buske, Brigitte Gerhard, Arthur E. Frankel

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Addition of cytosine arabinoside (Ara-C) to truncated diphtheria toxin (DT₃₈₈) fused to granulocyte macrophage-colony stimulating factor (GMCSF) or interleukin-3 (IL3) was studied in a NOD/SCID mouse model of human AML. Ara-C alone did not reduce the % human AML cells in mouse bone marrow (BM). DT₃₈₈IL3 or DT₃₈₈GMCSF alone reduced but did not eradicate engraftment for two of four and two of three samples, respectively. In contrast, Ara-C with DT₃₈₈IL3 eliminated AML from mouse BM with one of four samples while DT₃₈₈GMCSF with Ara-C eliminated or reduced AML cells as compared to mice receiving either agent alone with two of three samples.

Original language	English (US)
Pages (from-to)	1221-1226
Number of pages	6
Journal	Leukemia Research
Volume	28
Issue number	11
DOIs	https://doi.org/10.1016/j.leukres.2004.03.015
State	Published - Nov 2004

Keywords

AML
Ara-C
Diphtheria toxin fusion proteins
NOD/SCID mice

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.1016/j.leukres.2004.03.015

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The efficacy of diphtheria-growth factor fusion proteins is enhanced by co-administration of cytosine arabinoside in an immunodeficient mouse model of human acute myeloid leukemia. / Hogge, Donna E.; Feuring-Buske, Michaela; Gerhard, Brigitte et al.
In: Leukemia Research, Vol. 28, No. 11, 11.2004, p. 1221-1226.

Research output: Contribution to journal › Article › peer-review

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abstract = "Addition of cytosine arabinoside (Ara-C) to truncated diphtheria toxin (DT388) fused to granulocyte macrophage-colony stimulating factor (GMCSF) or interleukin-3 (IL3) was studied in a NOD/SCID mouse model of human AML. Ara-C alone did not reduce the % human AML cells in mouse bone marrow (BM). DT388IL3 or DT388GMCSF alone reduced but did not eradicate engraftment for two of four and two of three samples, respectively. In contrast, Ara-C with DT388IL3 eliminated AML from mouse BM with one of four samples while DT388GMCSF with Ara-C eliminated or reduced AML cells as compared to mice receiving either agent alone with two of three samples.",

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The efficacy of diphtheria-growth factor fusion proteins is enhanced by co-administration of cytosine arabinoside in an immunodeficient mouse model of human acute myeloid leukemia

Abstract

Keywords

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