The efficacy of fetal sonographic biometry in Down syndrome screening

Mark T. Peters, Charles J. Lockwood, Wayne A. Miller

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Sonographic biometry has been proposed as a second-trimester Down syndrome screening modality. Approaches have relied on the apparent "shortened" femur length of fetuses with Down syndrome. Unfortunately, significant intercenter variation has been reported in the magnitude of this femur length reduction. In an effort to overcome many of these potential biases and better estimate the magnitude of femur length shortening in fetuses with Down syndrome, a retrospective review of femur lenght differences between 16 Down syndrome and 194 control fetuses was carried out. All scans were performed by one examiner who used the same equipment and measurement technique. A significant reduction in the observed to expected femur length ratio for a given biparietal diameter was identified in the Down versus control fetuses (0.9574 95% confidence interval 0.9197, 0.9952 versus 0.9999 95% confidence interval 0.9913, 1.0086). (p < 0.008). However, the magnitude of this reduction was not sufficient to permit the use of this sonographic approach as an isolated marker for fetal Down syndrome.

Original languageEnglish (US)
Pages (from-to)297-300
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume161
Issue number2
DOIs
StatePublished - 1989

Fingerprint

Biometry
Down Syndrome
Femur
Fetus
Confidence Intervals
Second Pregnancy Trimester
Equipment and Supplies

Keywords

  • Down syndrome screening
  • shortened femur
  • Sonographic biometry

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

The efficacy of fetal sonographic biometry in Down syndrome screening. / Peters, Mark T.; Lockwood, Charles J.; Miller, Wayne A.

In: American Journal of Obstetrics and Gynecology, Vol. 161, No. 2, 1989, p. 297-300.

Research output: Contribution to journalArticle

Peters, Mark T. ; Lockwood, Charles J. ; Miller, Wayne A. / The efficacy of fetal sonographic biometry in Down syndrome screening. In: American Journal of Obstetrics and Gynecology. 1989 ; Vol. 161, No. 2. pp. 297-300.
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