The efficacy of particulate embolization combined with stereotactic radiosurgery for treatment of large arteriovenous malformations of the brain

J. A. Mathis, J. D. Barr, J. A. Horton, C. A. Jungreis, L. D. Lunsford, D. S. Kondziolka, D. Vincent, S. Pentheny

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

PURPOSE: To evaluate the efficacy of combined particulate embolization and single stage stereotactic radiosurgery in the treatment of large arteriovenous malformations (AVMs) of the brain. METHODS: Twenty-four patients with barge brain AVMs (diameter >3.0 cm; volume > 14 cm3), who had previously undergone particulate embolization and stereotactic radiosurgery, were retrospectively evaluated 2 or more years after radiosurgery. RESULTS: In 12 (50%) of these patients there was complete AVM obliteration, comparing favorably with a 58% obliteration rate in a group of AVMs having a 4- to 10- cm3 volume, treated by radiosurgery alone. Recanalization of embolized, but not radiated, AVM segments was identified in 3 (12%) patients. However, long- term occlusion was demonstrated in the embolized portions of most AVMs subsequently treated by radiosurgery. Complications included 1 (4%) patient with a mild upper extremity paresis after radiosurgery and 2 (8%) patients with transient neurologic deficits after embolization. CONCLUSION: Combined embolization and stereotactic radiosurgery was more efficacious than radiosurgery alone for large brain AVMs. Recanalization after embolization did occur but was a relatively minor cause of treatment failure.

Original languageEnglish (US)
Pages (from-to)299-306
Number of pages8
JournalAmerican Journal of Neuroradiology
Volume16
Issue number2
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Fingerprint Dive into the research topics of 'The efficacy of particulate embolization combined with stereotactic radiosurgery for treatment of large arteriovenous malformations of the brain'. Together they form a unique fingerprint.

  • Cite this

    Mathis, J. A., Barr, J. D., Horton, J. A., Jungreis, C. A., Lunsford, L. D., Kondziolka, D. S., Vincent, D., & Pentheny, S. (1995). The efficacy of particulate embolization combined with stereotactic radiosurgery for treatment of large arteriovenous malformations of the brain. American Journal of Neuroradiology, 16(2), 299-306.