The elusive activity of the Yersinia protein kinase A kinase domain is revealed

Michelle A. Laskowski-Arce, Kim Orth

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Yersinia spp. pathogens use their type III secretion system to translocate effectors that manipulate host signaling pathways during infection. Although molecular targets for five of the six known Yersinia effectors are known, the target for the serine/threonine kinase domain of Yersinia protein kinase A (YpkA) has remained elusive. Recently, Navarro et al. (2007) demonstrated that YpkA phosphorylates Gαq, and inhibits Gαq-mediated signaling. Inhibition by YpkA could contribute to one of the most documented symptoms of Yersinia pestis infection, extensive bleeding.

Original languageEnglish (US)
Pages (from-to)437-440
Number of pages4
JournalTrends in Microbiology
Volume15
Issue number10
DOIs
StatePublished - Oct 2007

Fingerprint

Yersinia
Cyclic AMP-Dependent Protein Kinases
Phosphotransferases
Yersinia Infections
Yersinia pestis
Protein-Serine-Threonine Kinases
Hemorrhage
Infection

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology

Cite this

The elusive activity of the Yersinia protein kinase A kinase domain is revealed. / Laskowski-Arce, Michelle A.; Orth, Kim.

In: Trends in Microbiology, Vol. 15, No. 10, 10.2007, p. 437-440.

Research output: Contribution to journalArticle

@article{81b615a2c4ce47598dfd0187c8e73366,
title = "The elusive activity of the Yersinia protein kinase A kinase domain is revealed",
abstract = "Yersinia spp. pathogens use their type III secretion system to translocate effectors that manipulate host signaling pathways during infection. Although molecular targets for five of the six known Yersinia effectors are known, the target for the serine/threonine kinase domain of Yersinia protein kinase A (YpkA) has remained elusive. Recently, Navarro et al. (2007) demonstrated that YpkA phosphorylates Gαq, and inhibits Gαq-mediated signaling. Inhibition by YpkA could contribute to one of the most documented symptoms of Yersinia pestis infection, extensive bleeding.",
author = "Laskowski-Arce, {Michelle A.} and Kim Orth",
year = "2007",
month = "10",
doi = "10.1016/j.tim.2007.09.002",
language = "English (US)",
volume = "15",
pages = "437--440",
journal = "Trends in Microbiology",
issn = "0966-842X",
publisher = "Elsevier Limited",
number = "10",

}

TY - JOUR

T1 - The elusive activity of the Yersinia protein kinase A kinase domain is revealed

AU - Laskowski-Arce, Michelle A.

AU - Orth, Kim

PY - 2007/10

Y1 - 2007/10

N2 - Yersinia spp. pathogens use their type III secretion system to translocate effectors that manipulate host signaling pathways during infection. Although molecular targets for five of the six known Yersinia effectors are known, the target for the serine/threonine kinase domain of Yersinia protein kinase A (YpkA) has remained elusive. Recently, Navarro et al. (2007) demonstrated that YpkA phosphorylates Gαq, and inhibits Gαq-mediated signaling. Inhibition by YpkA could contribute to one of the most documented symptoms of Yersinia pestis infection, extensive bleeding.

AB - Yersinia spp. pathogens use their type III secretion system to translocate effectors that manipulate host signaling pathways during infection. Although molecular targets for five of the six known Yersinia effectors are known, the target for the serine/threonine kinase domain of Yersinia protein kinase A (YpkA) has remained elusive. Recently, Navarro et al. (2007) demonstrated that YpkA phosphorylates Gαq, and inhibits Gαq-mediated signaling. Inhibition by YpkA could contribute to one of the most documented symptoms of Yersinia pestis infection, extensive bleeding.

UR - http://www.scopus.com/inward/record.url?scp=35649004349&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35649004349&partnerID=8YFLogxK

U2 - 10.1016/j.tim.2007.09.002

DO - 10.1016/j.tim.2007.09.002

M3 - Article

C2 - 17920275

AN - SCOPUS:35649004349

VL - 15

SP - 437

EP - 440

JO - Trends in Microbiology

JF - Trends in Microbiology

SN - 0966-842X

IS - 10

ER -