The elusive activity of the Yersinia protein kinase A kinase domain is revealed

Michelle A. Laskowski-Arce, Kim Orth

Research output: Contribution to journalArticle

2 Scopus citations


Yersinia spp. pathogens use their type III secretion system to translocate effectors that manipulate host signaling pathways during infection. Although molecular targets for five of the six known Yersinia effectors are known, the target for the serine/threonine kinase domain of Yersinia protein kinase A (YpkA) has remained elusive. Recently, Navarro et al. (2007) demonstrated that YpkA phosphorylates Gαq, and inhibits Gαq-mediated signaling. Inhibition by YpkA could contribute to one of the most documented symptoms of Yersinia pestis infection, extensive bleeding.

Original languageEnglish (US)
Pages (from-to)437-440
Number of pages4
JournalTrends in Microbiology
Issue number10
Publication statusPublished - Oct 2007


ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology

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