The emerging issue of MICA antibodies: Antibodies to MICA and other antigens of endothelial cells

Peter Stastny, Yizhou Zou, Yisun Fan, Zhiqiang Qin, Bhavna Lavingia

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Citations (Scopus)

Abstract

The major histocompatibility complex (MHC) encodes the HLA class I antigens expressed on the surface of most nucleated cells and the HLA class II antigens which are expressed mostly in B lymphocytes, monocytes and dendritic cells. Mismatched HLA anti-gens are the main source of the immune response that leads to the rejection of allografts. In some patients however, rejection may occur without a detectable response to donor HLA antigens. We have been interested in characterizing antibodies that develop in transplant recipients who do not appear to have antibodies against HLA. For this purpose, we focused our attention to antigens which are expressed on the surface of endothelial cells and are not found on peripheral blood lymphocytes. These include the MICA and MICB antigens, which are encoded by loci in the MHC; certain autoantigens expressed on the endothelium; and a family of polymorphic antigens expressed on endothelial cells which are distinct from HLA and elicit production of antibodies that appear also to be associated with graft failure. Antibodies against MICA have been associated with allograft rejection. MICB antibodies are only rarely found. The autoantibodies and the endothelial specific alloantibodies are being characterized in ongoing studies.

Original languageEnglish (US)
Title of host publicationContributions to Nephrology
Pages99-106
Number of pages8
Volume162
DOIs
StatePublished - 2009

Publication series

NameContributions to Nephrology
Volume162
ISSN (Print)03025144

Fingerprint

Endothelial Cells
HLA Antigens
Antibodies
Major Histocompatibility Complex
Allografts
Antigens
Isoantibodies
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Autoantigens
Autoantibodies
Dendritic Cells
Endothelium
Antibody Formation
Monocytes
B-Lymphocytes
Lymphocytes
Transplants
MHC class I-related chain A

ASJC Scopus subject areas

  • Nephrology

Cite this

Stastny, P., Zou, Y., Fan, Y., Qin, Z., & Lavingia, B. (2009). The emerging issue of MICA antibodies: Antibodies to MICA and other antigens of endothelial cells. In Contributions to Nephrology (Vol. 162, pp. 99-106). (Contributions to Nephrology; Vol. 162). https://doi.org/10.1159/000170842

The emerging issue of MICA antibodies : Antibodies to MICA and other antigens of endothelial cells. / Stastny, Peter; Zou, Yizhou; Fan, Yisun; Qin, Zhiqiang; Lavingia, Bhavna.

Contributions to Nephrology. Vol. 162 2009. p. 99-106 (Contributions to Nephrology; Vol. 162).

Research output: Chapter in Book/Report/Conference proceedingChapter

Stastny, P, Zou, Y, Fan, Y, Qin, Z & Lavingia, B 2009, The emerging issue of MICA antibodies: Antibodies to MICA and other antigens of endothelial cells. in Contributions to Nephrology. vol. 162, Contributions to Nephrology, vol. 162, pp. 99-106. https://doi.org/10.1159/000170842
Stastny P, Zou Y, Fan Y, Qin Z, Lavingia B. The emerging issue of MICA antibodies: Antibodies to MICA and other antigens of endothelial cells. In Contributions to Nephrology. Vol. 162. 2009. p. 99-106. (Contributions to Nephrology). https://doi.org/10.1159/000170842
Stastny, Peter ; Zou, Yizhou ; Fan, Yisun ; Qin, Zhiqiang ; Lavingia, Bhavna. / The emerging issue of MICA antibodies : Antibodies to MICA and other antigens of endothelial cells. Contributions to Nephrology. Vol. 162 2009. pp. 99-106 (Contributions to Nephrology).
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