The emerging issue of MICA antibodies: Antibodies to MICA and other antigens of endothelial cells

Peter Stastny, Yizhou Zou, Yisun Fan, Zhiqiang Qin, Bhavna Lavingia

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations

Abstract

The major histocompatibility complex (MHC) encodes the HLA class I antigens expressed on the surface of most nucleated cells and the HLA class II antigens which are expressed mostly in B lymphocytes, monocytes and dendritic cells. Mismatched HLA anti-gens are the main source of the immune response that leads to the rejection of allografts. In some patients however, rejection may occur without a detectable response to donor HLA antigens. We have been interested in characterizing antibodies that develop in transplant recipients who do not appear to have antibodies against HLA. For this purpose, we focused our attention to antigens which are expressed on the surface of endothelial cells and are not found on peripheral blood lymphocytes. These include the MICA and MICB antigens, which are encoded by loci in the MHC; certain autoantigens expressed on the endothelium; and a family of polymorphic antigens expressed on endothelial cells which are distinct from HLA and elicit production of antibodies that appear also to be associated with graft failure. Antibodies against MICA have been associated with allograft rejection. MICB antibodies are only rarely found. The autoantibodies and the endothelial specific alloantibodies are being characterized in ongoing studies.

Original languageEnglish (US)
Title of host publicationHumoral Immunity in Kidney Transplantation
Subtitle of host publicationWhat Clinicians Need to Know
EditorsGiuseppe Remuzzi, Norberto Perico, Stefano Chiaramonte, Claudio Ronco
Pages99-106
Number of pages8
DOIs
StatePublished - Jul 31 2009

Publication series

NameContributions to Nephrology
Volume162
ISSN (Print)0302-5144

ASJC Scopus subject areas

  • Nephrology

Fingerprint Dive into the research topics of 'The emerging issue of MICA antibodies: Antibodies to MICA and other antigens of endothelial cells'. Together they form a unique fingerprint.

  • Cite this

    Stastny, P., Zou, Y., Fan, Y., Qin, Z., & Lavingia, B. (2009). The emerging issue of MICA antibodies: Antibodies to MICA and other antigens of endothelial cells. In G. Remuzzi, N. Perico, S. Chiaramonte, & C. Ronco (Eds.), Humoral Immunity in Kidney Transplantation: What Clinicians Need to Know (pp. 99-106). (Contributions to Nephrology; Vol. 162). https://doi.org/10.1159/000170842