The emerging role for repetitive transcranial magnetic stimulation in optimizing the treatment of adolescent depression

Paul E. Croarkin, Christopher A. Wall, Shawn M. McClintock, Frank Andrew Kozel, Mustafa M. Husain, Shirlene M. Sampson

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Major depressive disorder (MDD) in adolescents is a common illness and significant public health problem. Treatment is challenging because of recurrences and limited modalities. Selective serotonin reuptake inhibitors and cognitive behavioral therapy are considered the standard of care in severe or treatment-resistant MDD in this age group. However, responses to these interventions are often suboptimal. A growing body of research supports the efficacy of repetitive transcranial magnetic stimulation (rTMS) for the treatment of MDD in adults. Induced seizures are a primary safety concern, although this is rare with appropriate precautions. There is, however, limited experience with rTMS as a therapeutic intervention for adolescent psychiatric disturbances. This review will summarize the rTMS efficacy and safety data in adults and describe all published experience with adolescent MDD. Applications in other adolescent psychiatric illnesses such as schizophrenia and attention-deficit/hyperactivity disorder are reviewed. Safety and ethical issues are paramount with investigational treatments in adolescent psychiatric illnesses. However, further research with rTMS in adolescent MDD is imperative to establish standards for optimal stimulation site, treatment parameters, and its role in treatment algorithms. These may diverge from adult data. Early intervention with neuromodulation could also hold the promise of addressing the developmental course of dysfunctional neurocircuitry.

Original languageEnglish (US)
Pages (from-to)323-329
Number of pages7
JournalJournal of ECT
Volume26
Issue number4
DOIs
StatePublished - Dec 2010

Fingerprint

Transcranial Magnetic Stimulation
Major Depressive Disorder
Adolescent Psychiatry
Depression
Safety
Treatment-Resistant Depressive Disorder
Therapeutics
Investigational Therapies
Serotonin Uptake Inhibitors
Cognitive Therapy
Attention Deficit Disorder with Hyperactivity
Standard of Care
Research
Ethics
Schizophrenia
Seizures
Public Health
Age Groups
Recurrence

Keywords

  • adolescents
  • major depressive disorder
  • transcranial magnetic stimulation

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience (miscellaneous)

Cite this

The emerging role for repetitive transcranial magnetic stimulation in optimizing the treatment of adolescent depression. / Croarkin, Paul E.; Wall, Christopher A.; McClintock, Shawn M.; Kozel, Frank Andrew; Husain, Mustafa M.; Sampson, Shirlene M.

In: Journal of ECT, Vol. 26, No. 4, 12.2010, p. 323-329.

Research output: Contribution to journalArticle

Croarkin, Paul E. ; Wall, Christopher A. ; McClintock, Shawn M. ; Kozel, Frank Andrew ; Husain, Mustafa M. ; Sampson, Shirlene M. / The emerging role for repetitive transcranial magnetic stimulation in optimizing the treatment of adolescent depression. In: Journal of ECT. 2010 ; Vol. 26, No. 4. pp. 323-329.
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