The Emerging Role of Cdk5 in Cancer

Karine Pozo; James A. Bibb

doi:10.1016/j.trecan.2016.09.001

The Emerging Role of Cdk5 in Cancer

Karine Pozo, James A. Bibb

Research output: Contribution to journal › Review article › peer-review

115 Scopus citations

Abstract

Cdk5 is an atypical cyclin-dependent kinase that is well characterized for its role in the central nervous system rather than in the cell cycle. However, Cdk5 has been recently implicated in the development and progression of a variety of cancers including breast, lung, colon, pancreatic, melanoma, thyroid, and brain tumors. This broad protumorigenic role makes Cdk5 a promising drug target for the development of new cancer therapies. In this review, we discuss the contribution of Cdk5 to molecular mechanisms that confer upon tumors the ability to grow, proliferate, and disseminate to secondary organs, as well as resistance to chemotherapies. We subsequently discuss existing and new strategies for targeting Cdk5 and its downstream mechanisms as anticancer treatments.

Original language	English (US)
Pages (from-to)	606-618
Number of pages	13
Journal	Trends in Cancer
Volume	2
Issue number	10
DOIs	https://doi.org/10.1016/j.trecan.2016.09.001
State	Published - Oct 1 2016

Keywords

Cdk5
cancer
resistance

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.trecan.2016.09.001

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title = "The Emerging Role of Cdk5 in Cancer",

abstract = "Cdk5 is an atypical cyclin-dependent kinase that is well characterized for its role in the central nervous system rather than in the cell cycle. However, Cdk5 has been recently implicated in the development and progression of a variety of cancers including breast, lung, colon, pancreatic, melanoma, thyroid, and brain tumors. This broad protumorigenic role makes Cdk5 a promising drug target for the development of new cancer therapies. In this review, we discuss the contribution of Cdk5 to molecular mechanisms that confer upon tumors the ability to grow, proliferate, and disseminate to secondary organs, as well as resistance to chemotherapies. We subsequently discuss existing and new strategies for targeting Cdk5 and its downstream mechanisms as anticancer treatments.",

keywords = "Cdk5, cancer, resistance",

author = "Karine Pozo and Bibb, {James A.}",

note = "Funding Information: This work was supported by a North American Neuroendocrine Tumor Society fellowship (K.P.), U.S. National Institutes of Health Grants (MH79710, MH083711, DA016672, DA033485, and NS073855) and American Cancer Society MEN2 Thyroid Cancer Consortium Research Grant (RSGM-11-190-01) to J.A.B. We thank Erik Knudsen and Florian Plattner for helpful discussions and Kate Mackley for graphic art. We apologize to authors whose work was not cited due to space limitations. Some images are used under license from Shutterstock.com. Credits to S. Kaulitzki/S.K. Chavan/M. Vaculikova/J. Vitanovski/Shutterstock. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

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doi = "10.1016/j.trecan.2016.09.001",

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AU - Bibb, James A.

N1 - Funding Information: This work was supported by a North American Neuroendocrine Tumor Society fellowship (K.P.), U.S. National Institutes of Health Grants (MH79710, MH083711, DA016672, DA033485, and NS073855) and American Cancer Society MEN2 Thyroid Cancer Consortium Research Grant (RSGM-11-190-01) to J.A.B. We thank Erik Knudsen and Florian Plattner for helpful discussions and Kate Mackley for graphic art. We apologize to authors whose work was not cited due to space limitations. Some images are used under license from Shutterstock.com. Credits to S. Kaulitzki/S.K. Chavan/M. Vaculikova/J. Vitanovski/Shutterstock. Publisher Copyright: © 2016 Elsevier Inc.

PY - 2016/10/1

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N2 - Cdk5 is an atypical cyclin-dependent kinase that is well characterized for its role in the central nervous system rather than in the cell cycle. However, Cdk5 has been recently implicated in the development and progression of a variety of cancers including breast, lung, colon, pancreatic, melanoma, thyroid, and brain tumors. This broad protumorigenic role makes Cdk5 a promising drug target for the development of new cancer therapies. In this review, we discuss the contribution of Cdk5 to molecular mechanisms that confer upon tumors the ability to grow, proliferate, and disseminate to secondary organs, as well as resistance to chemotherapies. We subsequently discuss existing and new strategies for targeting Cdk5 and its downstream mechanisms as anticancer treatments.

AB - Cdk5 is an atypical cyclin-dependent kinase that is well characterized for its role in the central nervous system rather than in the cell cycle. However, Cdk5 has been recently implicated in the development and progression of a variety of cancers including breast, lung, colon, pancreatic, melanoma, thyroid, and brain tumors. This broad protumorigenic role makes Cdk5 a promising drug target for the development of new cancer therapies. In this review, we discuss the contribution of Cdk5 to molecular mechanisms that confer upon tumors the ability to grow, proliferate, and disseminate to secondary organs, as well as resistance to chemotherapies. We subsequently discuss existing and new strategies for targeting Cdk5 and its downstream mechanisms as anticancer treatments.

KW - Cdk5

KW - cancer

KW - resistance

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The Emerging Role of Cdk5 in Cancer

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Keywords

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