The epidermal growth factor receptor: A role in repair of radiation-induced DNA damage

David J. Chen, Chaitanya S. Nirodi

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

The epidermal growth factor receptor (EGFR), which is frequently expressed in tumors of epithelial origin, is an important determinant of tumor responses to ionizing radiation. Elevated EGFR expression and activity frequently correlate with tumor resistance to radiotherapy in patients. EGFR is thought to confer tumor resistance to radiation through the activation of survival and cell proliferation pathways. Recent discoveries have identified a novel radioprotective function of EGFR which involves the radiation-induced nuclear translocation of the receptor and its interactions with the DNA-dependent protein kinase,a key component of the nonhomologous end-joining DNA repair pathway. Targeting the DNA repair function of EGFR may serve as a therapeutic model for sensitizing tumors to radiotherapy in patients.

Original languageEnglish (US)
Pages (from-to)6555-6560
Number of pages6
JournalClinical Cancer Research
Volume13
Issue number22
DOIs
StatePublished - Nov 15 2007

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Epidermal Growth Factor Receptor
DNA Damage
Radiation
DNA End-Joining Repair
Neoplasms
Radiotherapy
DNA-Activated Protein Kinase
Cytoplasmic and Nuclear Receptors
Ionizing Radiation
DNA Repair
Cell Proliferation
Survival
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The epidermal growth factor receptor : A role in repair of radiation-induced DNA damage. / Chen, David J.; Nirodi, Chaitanya S.

In: Clinical Cancer Research, Vol. 13, No. 22, 15.11.2007, p. 6555-6560.

Research output: Contribution to journalArticle

Chen, David J. ; Nirodi, Chaitanya S. / The epidermal growth factor receptor : A role in repair of radiation-induced DNA damage. In: Clinical Cancer Research. 2007 ; Vol. 13, No. 22. pp. 6555-6560.
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