The epinephrine/norepinephrine /autoinducer-3 interkingdom signaling system in Escherichia coli o157: H7

Cristiano G. Moreira, Vanessa Sperandio

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Citations (Scopus)

Abstract

Epinephrine/norepinephrine/AI-3 signaling is used as an interkingdom chemical signaling system between microbes and their hosts. This system is also exploited by pathogens to regulate virulence traits. In enterohemorrhagic E. coli (EHEC) O157:H7, it is essential for pathogenesis and flagella motility. These three signals activate expression of a pathogenicity island named locus of enterocyte effacement (LEE), Shiga toxin, and the flagella regulon. These signals are sensed by the two-component system QseBC, whereas the bacterial membrane receptor QseC autophosphorylates and phosphorylates the QseB response regulator initiating a complex phosphorelay signaling cascade that activates the expression of a second two-component system, QseEF. The QseEF two-component system is also involved in the expression of the virulence genes, and it senses epinephrine, phosphate, and sulfate. This complex signaling cascade still needs to be completely elucidated.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages247-261
Number of pages15
Volume874
DOIs
StatePublished - 2016

Publication series

NameAdvances in Experimental Medicine and Biology
Volume874
ISSN (Print)00652598
ISSN (Electronic)22148019

Fingerprint

Escherichia coli O157
Flagella
Escherichia coli
Epinephrine
Virulence
Norepinephrine
Shiga Toxin
Enterohemorrhagic Escherichia coli
Genomic Islands
Regulon
Enterocytes
Phosphates
Gene Expression
Membranes
Pathogens
Sulfates
Genes
epinephrine sulfate

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Moreira, C. G., & Sperandio, V. (2016). The epinephrine/norepinephrine /autoinducer-3 interkingdom signaling system in Escherichia coli o157: H7. In Advances in Experimental Medicine and Biology (Vol. 874, pp. 247-261). (Advances in Experimental Medicine and Biology; Vol. 874). Springer New York LLC. https://doi.org/10.1007/978-3-319-20215-0_12

The epinephrine/norepinephrine /autoinducer-3 interkingdom signaling system in Escherichia coli o157 : H7. / Moreira, Cristiano G.; Sperandio, Vanessa.

Advances in Experimental Medicine and Biology. Vol. 874 Springer New York LLC, 2016. p. 247-261 (Advances in Experimental Medicine and Biology; Vol. 874).

Research output: Chapter in Book/Report/Conference proceedingChapter

Moreira, CG & Sperandio, V 2016, The epinephrine/norepinephrine /autoinducer-3 interkingdom signaling system in Escherichia coli o157: H7. in Advances in Experimental Medicine and Biology. vol. 874, Advances in Experimental Medicine and Biology, vol. 874, Springer New York LLC, pp. 247-261. https://doi.org/10.1007/978-3-319-20215-0_12
Moreira CG, Sperandio V. The epinephrine/norepinephrine /autoinducer-3 interkingdom signaling system in Escherichia coli o157: H7. In Advances in Experimental Medicine and Biology. Vol. 874. Springer New York LLC. 2016. p. 247-261. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-20215-0_12
Moreira, Cristiano G. ; Sperandio, Vanessa. / The epinephrine/norepinephrine /autoinducer-3 interkingdom signaling system in Escherichia coli o157 : H7. Advances in Experimental Medicine and Biology. Vol. 874 Springer New York LLC, 2016. pp. 247-261 (Advances in Experimental Medicine and Biology).
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