The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling

Qian Zhou, Heng Lin, Suyun Wang, Shuai Wang, Yong Ran, Ying Liu, Wen Ye, Xiaozhe Xiong, Bo Zhong, Hong Bing Shu, Yan Yi Wang

Research output: Contribution to journalArticlepeer-review

92 Scopus citations

Abstract

ZDHHC1 mediates DNA-virus-triggered, MITA-dependent innate immune signaling in vitroZDHHC1 deficiency impairs innate immunity against DNA but not RNA viruses in vivoZDHHC1 localizes to the ER and Golgi and associates with MITA/STINGZDHHC1 functions through MITA/STING and modulates its activity

Original languageEnglish (US)
Pages (from-to)450-461
Number of pages12
JournalCell Host and Microbe
Volume16
Issue number4
DOIs
StatePublished - Oct 8 2014
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

Fingerprint

Dive into the research topics of 'The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling'. Together they form a unique fingerprint.

Cite this