TY - JOUR
T1 - The ER in 3D
T2 - A multifunctional dynamic membrane network
AU - Friedman, Jonathan R.
AU - Voeltz, Gia K.
N1 - Funding Information:
This work was supported by NIH R01 GM083977 to G.K.V. and an NIH predoctoral training grant GM08759 to J.R.F. We thank M. West for providing electron microscope images and A. Rowland for helpful comments.
PY - 2011/12
Y1 - 2011/12
N2 - The endoplasmic reticulum (ER) is a large, singular, membrane-bound organelle that has an elaborate 3D structure with a diversity of structural domains. It contains regions that are flat and cisternal, ones that are highly curved and tubular, and others adapted to form contacts with nearly every other organelle and with the plasma membrane. The 3D structure of the ER is determined by both integral ER membrane proteins and by interactions with the cytoskeleton. In this review, we describe some of the factors that are known to regulate ER structure and discuss how this structural organization and the dynamic nature of the ER membrane network allow it to perform its many different functions.
AB - The endoplasmic reticulum (ER) is a large, singular, membrane-bound organelle that has an elaborate 3D structure with a diversity of structural domains. It contains regions that are flat and cisternal, ones that are highly curved and tubular, and others adapted to form contacts with nearly every other organelle and with the plasma membrane. The 3D structure of the ER is determined by both integral ER membrane proteins and by interactions with the cytoskeleton. In this review, we describe some of the factors that are known to regulate ER structure and discuss how this structural organization and the dynamic nature of the ER membrane network allow it to perform its many different functions.
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U2 - 10.1016/j.tcb.2011.07.004
DO - 10.1016/j.tcb.2011.07.004
M3 - Review article
C2 - 21900009
AN - SCOPUS:81355137930
SN - 0962-8924
VL - 21
SP - 709
EP - 717
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 12
ER -