The erythrocyte sedimentation rate in congestive heart failure

Howard L. Haber, Jeffrey A. Leavy, Paul D. Kessler, Marrick L. Kukin, Stephen S. Gottlieb, Milton Packer

Research output: Contribution to journalArticle

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Abstract

Background and Methods. Physicians have long believed that the erythrocyte sedimentation rate is low in patients with congestive heart failure, but this concept is based on a misinterpretation of the results in a single report published in 1936. To reevaluate this concept in the modern era, we measured the sedimentation rate in 242 patients who were referred for treatment of chronic heart failure. Results. The sedimentation rate was low (less than [5 mm per hour) in only 24 patients (10 percent) but was increased (above 25 mm per hour) in 50 percent. Patients with low or normal sedimentation rates (≤25 mm per hour) had more severe hemodynamic abnormalities than patients with elevated rates: lower cardiac index (mean ±SEM, 1.7±0.1 vs. 2.0±0.1 liters per minute per square meter of body-surface area) and higher mean right atrial pressure (mean ±SEM, 12±1 vs. 9±1 mm Hg) (both P<0.0001). New York Heart Association functional class IV symptoms were present in 66 percent of the patients with a low or normal sedimentation rate, as compared with 42 percent of those with elevated rates (P<0.0001). After one to three months of therapy, patients whose sedimentation rates decreased showed little hemodynamic or clinical response to treatment, whereas both cardiac performance and functional status improved in patients whose rates increased (P<0.02 for the comparison between groups). The sedimentation rate was correlated with the plasma fibrinogen level (r = 0.64, P = 0.0025), and changes in the sedimentation rate during treatment were correlated inversely with changes in mean right atrial pressure (r = -0.57, P = 0.0002). During long-term follow-up, patients with low or normal sedimentation rates had a worse one-year survival than patients with elevated rates (41 vs. 66 percent, P = 0.01). Conclusions. These data indicate that the erythrocyte sedimentation rate is correlated with the severity of illness in patients with chronic heart failure. Because of its lack of discriminatory power, however, the test is of limited value in the clinical management of this disorder.

Original languageEnglish (US)
Pages (from-to)353-358
Number of pages6
JournalNew England Journal of Medicine
Volume324
Issue number6
StatePublished - Feb 7 1991

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Blood Sedimentation
Heart Failure
Atrial Pressure
Hemodynamics
Body Surface Area
Therapeutics
Fibrinogen
Physicians

ASJC Scopus subject areas

  • Medicine(all)

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Haber, H. L., Leavy, J. A., Kessler, P. D., Kukin, M. L., Gottlieb, S. S., & Packer, M. (1991). The erythrocyte sedimentation rate in congestive heart failure. New England Journal of Medicine, 324(6), 353-358.

The erythrocyte sedimentation rate in congestive heart failure. / Haber, Howard L.; Leavy, Jeffrey A.; Kessler, Paul D.; Kukin, Marrick L.; Gottlieb, Stephen S.; Packer, Milton.

In: New England Journal of Medicine, Vol. 324, No. 6, 07.02.1991, p. 353-358.

Research output: Contribution to journalArticle

Haber, HL, Leavy, JA, Kessler, PD, Kukin, ML, Gottlieb, SS & Packer, M 1991, 'The erythrocyte sedimentation rate in congestive heart failure', New England Journal of Medicine, vol. 324, no. 6, pp. 353-358.
Haber HL, Leavy JA, Kessler PD, Kukin ML, Gottlieb SS, Packer M. The erythrocyte sedimentation rate in congestive heart failure. New England Journal of Medicine. 1991 Feb 7;324(6):353-358.
Haber, Howard L. ; Leavy, Jeffrey A. ; Kessler, Paul D. ; Kukin, Marrick L. ; Gottlieb, Stephen S. ; Packer, Milton. / The erythrocyte sedimentation rate in congestive heart failure. In: New England Journal of Medicine. 1991 ; Vol. 324, No. 6. pp. 353-358.
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