The erythroid/myeloid lineage fate paradigm takes a new player

Jian Xu, Stuart H. Orkin

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The erythroid versus myeloid lineage fate decision controlled by cross-antagonism between GATA1 and PU.1 serves as a mechanistic paradigm for transcription factor interplay during lineage specification. In this issue of The EMBO Journal, Monteiro et al (2011) examined this paradigm in blood populations in zebrafish embryos, and demonstrated that, unexpectedly, the regulatory interactions between GATA1 and PU.1 lead to different outcomes depending on the cellular contexts and the development stages. GATA1/PU.1 cross-antagonism is also modulated by a third factor transcriptional intermediate factor 1γ (TIF1γ), a chromatin-associated haematopoietic regulator.

Original languageEnglish (US)
Pages (from-to)983-985
Number of pages3
JournalEMBO Journal
Volume30
Issue number6
DOIs
StatePublished - Mar 16 2011

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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