The ESCRT Pathway

William M. Henne, Nicholas J. Buchkovich, Scott D. Emr

Research output: Contribution to journalReview article

670 Scopus citations

Abstract

Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key mediator of MVB biogenesis, but it also plays critical roles in retroviral budding and cytokinetic abscission. Despite these diverse roles, the ESCRT pathway can be simply seen as a cargo-recognition and membrane-sculpting machine viewable from three distinct perspectives: (1) the ESCRT proteins themselves, (2) the cargo they sort, and (3) the membrane they deform. Here, we review ESCRT function from these perspectives and discuss how ESCRTs may drive vesicle budding.

Original languageEnglish (US)
Pages (from-to)77-91
Number of pages15
JournalDevelopmental cell
Volume21
Issue number1
DOIs
StatePublished - Jul 19 2011

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'The ESCRT Pathway'. Together they form a unique fingerprint.

  • Cite this