The ESCRT Pathway

William M. Henne, Nicholas J. Buchkovich, Scott D. Emr

Research output: Contribution to journalArticle

622 Citations (Scopus)

Abstract

Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key mediator of MVB biogenesis, but it also plays critical roles in retroviral budding and cytokinetic abscission. Despite these diverse roles, the ESCRT pathway can be simply seen as a cargo-recognition and membrane-sculpting machine viewable from three distinct perspectives: (1) the ESCRT proteins themselves, (2) the cargo they sort, and (3) the membrane they deform. Here, we review ESCRT function from these perspectives and discuss how ESCRTs may drive vesicle budding.

Original languageEnglish (US)
Pages (from-to)77-91
Number of pages15
JournalDevelopmental Cell
Volume21
Issue number1
DOIs
StatePublished - Jul 19 2011

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Endosomal Sorting Complexes Required for Transport
Multivesicular Bodies
Membranes
Vacuoles
Lysosomes
Carrier Proteins
Degradation

ASJC Scopus subject areas

  • Developmental Biology

Cite this

The ESCRT Pathway. / Henne, William M.; Buchkovich, Nicholas J.; Emr, Scott D.

In: Developmental Cell, Vol. 21, No. 1, 19.07.2011, p. 77-91.

Research output: Contribution to journalArticle

Henne, WM, Buchkovich, NJ & Emr, SD 2011, 'The ESCRT Pathway', Developmental Cell, vol. 21, no. 1, pp. 77-91. https://doi.org/10.1016/j.devcel.2011.05.015
Henne, William M. ; Buchkovich, Nicholas J. ; Emr, Scott D. / The ESCRT Pathway. In: Developmental Cell. 2011 ; Vol. 21, No. 1. pp. 77-91.
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