THE ESSENTIAL ROLE OF GLUCAGON IN THE PATHOGENESIS OF DIABETES MELLITUS

Roger H Unger, Lelio Orci

Research output: Contribution to journalArticle

346 Citations (Scopus)

Abstract

The following evidence suggests that diabetes mellitus may not be the simple consequence of relative or absolute insulin deficiency by itself, but may require the presence of glucagon: (1) relative or absolute hyperglucagonæmia has been identified in every form of endogenous hyperglycæmia, including total pancreatectomy in dogs; (2) insulin lack in the absence of glucagon does not cause endogenous hyperglycæmia, but when endogenous or exogenous glucagon is present, it quickly appears, irrespective of insulin levels at the time. These facts are compatible with a bihormonal-abnormality hypothesis, which holds that the major consequence of absolute or relative insulin lack is glucose under-utilisation and that absolute or relative glucagon excess is the principal factor in the over-production of glucose in diabetes.

Original languageEnglish (US)
Pages (from-to)14-16
Number of pages3
JournalThe Lancet
Volume305
Issue number7897
DOIs
StatePublished - Jan 4 1975

Fingerprint

Glucagon
Diabetes Mellitus
Insulin
Glucose
Pancreatectomy
Dogs

ASJC Scopus subject areas

  • Medicine(all)

Cite this

THE ESSENTIAL ROLE OF GLUCAGON IN THE PATHOGENESIS OF DIABETES MELLITUS. / Unger, Roger H; Orci, Lelio.

In: The Lancet, Vol. 305, No. 7897, 04.01.1975, p. 14-16.

Research output: Contribution to journalArticle

@article{a4513c14cdf440caa58ccabce902c14b,
title = "THE ESSENTIAL ROLE OF GLUCAGON IN THE PATHOGENESIS OF DIABETES MELLITUS",
abstract = "The following evidence suggests that diabetes mellitus may not be the simple consequence of relative or absolute insulin deficiency by itself, but may require the presence of glucagon: (1) relative or absolute hyperglucagon{\ae}mia has been identified in every form of endogenous hyperglyc{\ae}mia, including total pancreatectomy in dogs; (2) insulin lack in the absence of glucagon does not cause endogenous hyperglyc{\ae}mia, but when endogenous or exogenous glucagon is present, it quickly appears, irrespective of insulin levels at the time. These facts are compatible with a bihormonal-abnormality hypothesis, which holds that the major consequence of absolute or relative insulin lack is glucose under-utilisation and that absolute or relative glucagon excess is the principal factor in the over-production of glucose in diabetes.",
author = "Unger, {Roger H} and Lelio Orci",
year = "1975",
month = "1",
day = "4",
doi = "10.1016/S0140-6736(75)92375-2",
language = "English (US)",
volume = "305",
pages = "14--16",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "7897",

}

TY - JOUR

T1 - THE ESSENTIAL ROLE OF GLUCAGON IN THE PATHOGENESIS OF DIABETES MELLITUS

AU - Unger, Roger H

AU - Orci, Lelio

PY - 1975/1/4

Y1 - 1975/1/4

N2 - The following evidence suggests that diabetes mellitus may not be the simple consequence of relative or absolute insulin deficiency by itself, but may require the presence of glucagon: (1) relative or absolute hyperglucagonæmia has been identified in every form of endogenous hyperglycæmia, including total pancreatectomy in dogs; (2) insulin lack in the absence of glucagon does not cause endogenous hyperglycæmia, but when endogenous or exogenous glucagon is present, it quickly appears, irrespective of insulin levels at the time. These facts are compatible with a bihormonal-abnormality hypothesis, which holds that the major consequence of absolute or relative insulin lack is glucose under-utilisation and that absolute or relative glucagon excess is the principal factor in the over-production of glucose in diabetes.

AB - The following evidence suggests that diabetes mellitus may not be the simple consequence of relative or absolute insulin deficiency by itself, but may require the presence of glucagon: (1) relative or absolute hyperglucagonæmia has been identified in every form of endogenous hyperglycæmia, including total pancreatectomy in dogs; (2) insulin lack in the absence of glucagon does not cause endogenous hyperglycæmia, but when endogenous or exogenous glucagon is present, it quickly appears, irrespective of insulin levels at the time. These facts are compatible with a bihormonal-abnormality hypothesis, which holds that the major consequence of absolute or relative insulin lack is glucose under-utilisation and that absolute or relative glucagon excess is the principal factor in the over-production of glucose in diabetes.

UR - http://www.scopus.com/inward/record.url?scp=0016423677&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016423677&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(75)92375-2

DO - 10.1016/S0140-6736(75)92375-2

M3 - Article

C2 - 46337

AN - SCOPUS:0016423677

VL - 305

SP - 14

EP - 16

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 7897

ER -